期刊
FRONTIERS IN MICROBIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.697930
关键词
Bacillus subtilis; metabolism; cell elongation; MreB; cell division; FtsZ
类别
资金
- CNRS
- Aix-Marseille University
- ANR Grant [ANR-19-CE15-0011]
Bacteria must rapidly modulate cell cycle processes to adapt to changing nutritional conditions, and recent data suggest that cellular metabolism plays a central role in regulating the bacterial cell cycle. Proteins that can sense precursors or metabolites not only participate in metabolism, but also directly control cell cycle processes in response to changes in nutrient levels.
To survive and adapt to changing nutritional conditions, bacteria must rapidly modulate cell cycle processes, such as doubling time or cell size. Recent data have revealed that cellular metabolism is a central regulator of bacterial cell cycle. Indeed, proteins that can sense precursors or metabolites or enzymes, in addition to their enzymatic activities involved in metabolism, were shown to directly control cell cycle processes in response to changes in nutrient levels. Here we focus on cell elongation and cell division in the Gram-positive rod-shaped bacterium Bacillus subtilis and we report evidences linking these two cellular processes to environmental nutritional availability and thus metabolic cellular status.
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