Diverse Roles of TgMIC1/4/6 in the Toxoplasma Infection

Toxoplasma gondii microneme is a specialized secretory organelle that discharges its contents at the apical tip of this apicomplexan parasite in a sequential and regulated manner. Increasing number of studies on microneme proteins (MICs) have shown them as a predominant and important role in host cell attachment, invasion, motility and pathogenesis. In this review, we summarize the research advances in one of the most important MICs complexes, TgMIC1/4/6, which will contribute to improve the understanding of the molecular mechanism of T. gondii infection and provide a theoretical basis for the effective control against T. gondii.

Automated summary

Research on Toxoplasma gondii microneme proteins (MICs) has shown their important role in host cell attachment, invasion, motility, and pathogenesis. Specifically focusing on the TgMIC1/4/6 complex can help improve understanding of T. gondii infection and provide a basis for effective control strategies.