4.7 Review

Intracellular Interactions Between Arboviruses and Wolbachia in Aedes aegypti

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2021.690087

关键词

Aedes aegypti; dengue; zika; chikungunya; Wolbachia; vector control

资金

  1. Japan Society for the Promotion of Science (JSPS) [JPJSCCB20210006]
  2. JSPS [19KK0107]
  3. Grants-in-Aid for Scientific Research [19KK0107] Funding Source: KAKEN

向作者/读者索取更多资源

Research shows that Wolbachia can interfere with the transmission of arboviruses by reducing the susceptibility of mosquito cells to viral infection. However, the magnitude of this pathogen-blocking effect varies among different strains of Wolbachia, highlighting the need for further investigation.
Aedes aegypti is inherently susceptible to arboviruses. The geographical expansion of this vector host species has led to the persistence of Dengue, Zika, and Chikungunya human infections. These viruses take advantage of the mosquito's cell to create an environment conducive for their growth. Arboviral infection triggers transcriptomic and protein dysregulation in Ae. aegypti and in effect, host antiviral mechanisms are compromised. Currently, there are no existing vaccines able to protect human hosts from these infections and thus, vector control strategies such as Wolbachia mass release program is regarded as a viable option. Considerable evidence demonstrates how the presence of Wolbachia interferes with arboviruses by decreasing host cytoskeletal proteins and lipids essential for arboviral infection. Also, Wolbachia strengthens host immunity, cellular regeneration and causes the expression of microRNAs which could potentially be involved in virus inhibition. However, variation in the magnitude of Wolbachia's pathogen blocking effect that is not due to the endosymbiont's density has been recently reported. Furthermore, the cellular mechanisms involved in this phenotype differs depending on Wolbachia strain and host species. This prompts the need to explore the cellular interactions between Ae. aegypti-arboviruses-Wolbachia and how different Wolbachia strains overall affect the mosquito's cell. Understanding what happens at the cellular and molecular level will provide evidence on the sustainability of Wolbachia vector control.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据