期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2021.659505
关键词
symptomatic early pregnancy; tubal pregnancy; vaginal microbiota; Lactobacillus; non-Lactobacillus dominated microbiota
资金
- National Natural Science Foundation of China [81774358, 81373672]
- Post Project of Pearl River Scholar in Guangdong Province [A1AFD018191Z0103]
- Traditional Chinese Medicine Bureau of Guangdong Province [19, 5]
- Guangzhou University of Chinese Medicine [XK2019016, 2019KYTD202, 2019 II T33]
- Qi Huang Scholar in China (Letter of Chinese Traditional Medicine Education [2018] ) [284]
- Research Projects in Key Fields of Guangdong Province [2020B1111100003]
The study found that among women with symptomatic early pregnancy, those with a tubal pregnancy (TP) had higher diversity, different structures, and lower abundance of Lactobacillus in the vaginal microbiota (VM) compared to women with an intrauterine pregnancy (IUP).
The features of the vaginal microbiota (VM) community can reflect health status, and they could become new biomarkers for disease diagnosis. During pregnancy, domination of bacteria of the genus Lactobacillus in the VM community is regarded as a keystone because they stabilize the VM by producing antimicrobial compounds and competing adhesion. An altered VM composition provides a marker for adverse pregnancy outcomes. This nested case-control study aimed to characterize the VM in women with a tubal pregnancy (TP) presenting with pain and/or uterine bleeding in early pregnancy. Chinese women with a symptomatic early pregnancy of unknown location were the study cohort. 16S rDNA gene-sequencing of V3-V4 variable regions was done to assess the diversity, structures, taxonomic biomarkers, and classification of the VM community. The primary outcome was the location of the early pregnancy. The VM community in women with a TP showed higher diversity (PD-whole-tree, median: 8.26 vs. 7.08, P = 0.047; Shannon Diversity Index, median: 1.43 vs 0.99, P = 0.03) and showed different structures to those in women with an intrauterine pregnancy (IUP) (R = 0.23, P < 0.01). Bacteria of the genus Lactobacillus were significantly enriched in the IUP group, whereas bacteria of the genera Gardnerella and Prevotella were significantly enriched in the TP group. Lactobacillus abundance could be used to classify the pregnancy location (AUC = 0.81). Non-Lactobacillus-dominated microbiota (<= 0.85% Lactobacillus) was significantly associated with a TP (adjusted odds ratio: 4.42, 95% confidence interval: 1.33 to 14.71, P = 0.02). In conclusion, among women with a symptomatic early pregnancy, a higher diversity and lower abundance of Lactobacillus in the VM is associated with a TP.
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