期刊
ELIFE
卷 10, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.68181
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资金
- NIH [R01 NS109990, F31 EY029156, RO1 EY012793]
- McKnight Endowment Fund for Neuroscience
- NSF GRFP [DGE-1746045]
- NSF [1652617]
- National Science Foundation [PHY-1734030]
- Direct For Computer & Info Scie & Enginr
- Div Of Information & Intelligent Systems [1652617] Funding Source: National Science Foundation
The study reveals that On-Off DSGCs have spatially displaced glutamatergic receptive fields, contributing to specific spiking responses during interrupted motion trajectories. Theoretical analysis suggests that under different stimulus conditions, On-Off DSGCs may collectively signal the spatial location of moving objects in complex visual environments, showcasing the utilization of separate mechanisms by the direction-selective circuit.
Spatially distributed excitation and inhibition collectively shape a visual neuron's receptive field (RF) properties. In the direction-selective circuit of the mammalian retina, the role of strong null-direction inhibition of On-Off direction-selective ganglion cells (On-Off DSGCs) on their direction selectivity is well-studied. However, how excitatory inputs influence the On-Off DSGC's visual response is underexplored. Here, we report that On-Off DSGCs have a spatially displaced glutamatergic receptive field along their horizontal preferred-null motion axes. This displaced receptive field contributes to DSGC null-direction spiking during interrupted motion trajectories. Theoretical analyses indicate that population responses during interrupted motion may help populations of On-Off DSGCs signal the spatial location of moving objects in complex, naturalistic visual environments. Our study highlights that the direction-selective circuit exploits separate sets of mechanisms under different stimulus conditions, and these mechanisms may help encode multiple visual features.
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