期刊
ELIFE
卷 10, 期 -, 页码 -出版社
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.66483
关键词
cell delamination; apical constriction; dragging; mechanical forces; collective locomotion; dorsal forerunner cells; Zebrafish
类别
资金
- Fondo Nacional de Desarrollo Cientifico y Tecnologico [1190806, 1161274 1181823, 3160478]
- Instituto Milenio de Neurociencia Biomedica [ICN09_015]
- Millennium Nucleus Physics of Active Matter from ANID
- Fondo de Equipamiento Cientifico y Tecnologico [EQM130051]
- Fondo de Financiamiento de Centros de Investigacion en Areas Prioritarias [15150012]
- Comision Nacional de Investigacion Cientifica y Tecnologica [PIA ACT-1402, PIA ACT192015, REDES170212, REDES130020]
- H2020 European Research Council [742573]
- European Research Council (ERC) [742573] Funding Source: European Research Council (ERC)
The study uncovers a mechanism where progenitor cells coordinate their movement with adjacent tissues by incomplete delamination during development. This process ensures the collective fate and allocation of cells at the site of differentiation.
The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. Progenitors of the zebrafish laterality organ originate from the superficial epithelial enveloping layer by an apical constriction process of cell delamination. During this process, progenitors retain long-lasting apical contacts that enable the epithelial layer to pull a subset of progenitors on their way to the vegetal pole. The remaining delaminated cells follow the movement of apically attached progenitors by a protrusion-dependent cell-cell contact mechanism, avoiding sequestration by the adjacent endoderm, ensuring their collective fate and allocation at the site of differentiation. Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development.
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