☆ 4.8 Editorial Material

Research: Evolutionary medicine

ELIFE (2021)

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Review Genetics & Heredity

The influence of evolutionary history on human health and disease

Mary Lauren Benton et al.

Summary: Genetic variants influencing disease risk have human-specific origins but are rooted in ancient systems from before human origins. Genetic, cultural, and environmental differences in modern human populations contribute to varying disease prevalence, and integrating evolutionary history with genetic medicine can help realize the potential of personalized genomics.

NATURE REVIEWS GENETICS (2021)

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Article Biology

Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk

Juan M. Vazquez et al.

Summary: Within species, cancer risk is related to body size and lifespan, but between species, there is no correlation, suggesting large, long-lived species have evolved enhanced cancer protection mechanisms. Gene duplication appears to play a role in the evolution of increased body size and reduced cancer risk in certain lineages like Proboscideans.

ELIFE (2021)

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Review Biology

Gross ways to live long: Parasitic worms as an anti-inflammaging therapy?

Bruce Zhang et al.

Summary: Evolutionary medicine suggests that modern diseases may arise due to mismatches between our current environment and our evolved biology. Restoring commensal microbes and helminths may have therapeutic effects on allergic and autoimmune conditions, as well as age-related diseases such as inflammaging. Further research is needed to explore the potential broad-spectrum protective effects of worm infections against age-related illnesses.

ELIFE (2021)

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Article Biology

Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens

Claudia Igler et al.

Summary: Antimicrobial treatment success is threatened by drug resistance evolution, which can follow two patterns: a single mutation with large resistance benefit or multiple mutations with small benefits combining to yield high-level resistance. Resistance evolution is substantially limited if more than two mutations are required, and adaptive treatment delays treatment failure longer than aggressive treatment if multiple mutations are necessary.

ELIFE (2021)

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Article Biology

Understanding the evolution of multiple drug resistance in structured populations

David McLeod et al.

Summary: Studying the evolution of multidrug resistance (MDR) by focusing on the dynamical equations for linkage disequilibrium (LD) can simplify calculations, generate more insight, and provide a unified framework for understanding the role of population structure.

ELIFE (2021)

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Article Anthropology

Scanning the human genome for signatures of positive selection: Transformative opportunities and ethical obligations

Margarita Hernandez et al.

Summary: The relationship between evolutionary anthropology and genetics is complex, with genetics being both integral to the discipline and facing challenges such as reluctance to embrace genetic data and over-assertions of genetic definitiveness. While genetics has been used to reinforce racism and colonialism, the identification of past positive selection through genome-wide scans has transformed the field, revealing local adaptation and convergent evolution in diverse populations. Ethical considerations surrounding the ubiquity of these studies and the cross-application of genome-wide scan approach to existing datasets are also discussed.

EVOLUTIONARY ANTHROPOLOGY (2021)

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Article Biochemistry & Molecular Biology

Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk

Daniel Richard et al.

CELL (2020)

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Article Multidisciplinary Sciences

Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties

Masaki Takasugi et al.

NATURE COMMUNICATIONS (2020)

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Review Microbiology

Evolutionary causes and consequences of bacterial antibiotic persistence

Erik Bakkeren et al.

NATURE REVIEWS MICROBIOLOGY (2020)

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Editorial Material Medicine, General & Internal

The Illusion of Inclusion - The All of Us Research Program and Indigenous Peoples' DNA

Keolu Fox

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Ecology

(Re-) Defining evolutionary medicine

Jacqueline Moltzau Anderson et al.

ECOLOGY AND EVOLUTION (2020)

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Article Biology

Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

John Huddleston et al.

ELIFE (2020)

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Article Biology

An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen

Valerie J. Morley et al.

ELIFE (2020)

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Article Endocrinology & Metabolism

Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in MAori and Pacific (Polynesian) people living in Aotearoa/New Zealand

Mohanraj Krishnan et al.

DIABETOLOGIA (2018)

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Review Genetics & Heredity

The transition to modernity and chronic disease: mismatch and natural selection

Stephen Corbett et al.

NATURE REVIEWS GENETICS (2018)

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Review Microbiology

Drug resistance in Plasmodium

Kasturi Haldar et al.

NATURE REVIEWS MICROBIOLOGY (2018)

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Article Genetics & Heredity

Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy

Sean G. Byars et al.

PLOS GENETICS (2017)

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Article Biology

APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis

Anneli Cooper et al.

ELIFE (2017)

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Article Genetics & Heredity

A thrifty variant in CREBRF strongly influences body mass index in Samoans

Ryan L. Minster et al.

NATURE GENETICS (2016)

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Review Virology

Antiviral drug resistance as an adaptive process

Kristen K. Irwin et al.

VIRUS EVOLUTION (2016)

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Article Anthropology

How to make stone soup: Is the Paleo diet a missed opportunity for anthropologists?

Melanie L. Chang et al.

EVOLUTIONARY ANTHROPOLOGY (2016)

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Article Genetics & Heredity

A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations

Florian J. Clemente et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2014)

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Article Cell Biology

Adaptations to a Subterranean Environment and Longevity Revealed by the Analysis of Mole Rat Genomes

Xiaodong Fang et al.

CELL REPORTS (2014)

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Article Multidisciplinary Sciences

Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii

Inge Seim et al.

NATURE COMMUNICATIONS (2013)

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Review Biology

Evolutionary medicine: its scope, interest and potential

Stephen C. Stearns

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2012)

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Review Evolutionary Biology

How evolutionary principles improve the understanding of human health and disease

Peter D. Gluckman et al.

EVOLUTIONARY APPLICATIONS (2011)

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Article Multidisciplinary Sciences

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

Eun Bae Kim et al.

NATURE (2011)

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Article Multidisciplinary Sciences

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

Giulio Genovese et al.

SCIENCE (2010)

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Review Oncology

Cancer as an evolutionary and ecological process

Lauren M. F. Merlo et al.

NATURE REVIEWS CANCER (2006)

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