期刊
ELIFE
卷 10, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.66018
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资金
- Wellcome Trust [203261/Z/16/Z]
- European Research Council Consolidator grant [649111]
- Medical Research Council Core support [MC-U105188491]
- National Institutes of Health BRAIN Initiative grant [1RF1MH120679-01]
- National Institutes of Health F31 fellowship [DC016196]
- Boehringer Ingelheim Fonds PhD Fellowship
- Herchel Smith Studentship
- National Institutes of Health [R01DC008174]
- Howard Hughes Medical Institute
- European Research Council (ERC) [649111] Funding Source: European Research Council (ERC)
The hemibrain connectome provides large-scale connectivity and morphology information for the majority of the central brain of Drosophila melanogaster. Using this data set, a complete description of the Drosophila olfactory system is provided, with specific neural connection patterns identified. Leveraging a second data set, a quantitative assessment of inter- versus intra-individual stereotypy in neuronal morphology is presented, showing similarities in connectivity and morphology among neurons of the same type within and across brains.
The hemibrain connectome provides large-scale connectivity and morphology information for the majority of the central brain of Drosophila melanogaster. Using this data set, we provide a complete description of the Drosophila olfactory system, covering all first, second and lateral horn-associated third-order neurons. We develop a generally applicable strategy to extract information flow and layered organisation from connectome graphs, mapping olfactory input to descending interneurons. This identifies a range of motifs including highly lateralised circuits in the antennal lobe and patterns of convergence downstream of the mushroom body and lateral horn. Leveraging a second data set we provide a first quantitative assessment of inter- versus intra-individual stereotypy. Comparing neurons across two brains (three hemispheres) reveals striking similarity in neuronal morphology across brains. Connectivity correlates with morphology and neurons of the same morphological type show similar connection variability within the same brain as across two brains.
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