Exploration of C-H Activation Strategies in Construction of Functionalized 2-Aryl Benzoazoles: A Decisive Review

Transition metal-catalyzed C-H bond activation has proved to be a powerful weapon for the synthesis and functionalization of privileged class of heterocycles. The 2-aryl benzoazole (benzothiazoles, benzoxazoles and benzimidazoles) derivatives have surfaced in the scientific community with their potential applications in medicinal chemistry, agrochemistry and material science. The contribution of C-H activation strategies towards the functionalization of relevant 2-aryl benzoazoles has been amenable in the drug discovery process. This review envelopes a decade account of the C-H activation strategies adopted for the functionalization of 2-aryl benzoazoles.

Automated summary

The review summarizes the utilization of transition metal-catalyzed C-H bond activation for the functionalization of 2-aryl benzoazoles, contributing to the drug discovery process.