4.6 Article

In Situ Strategy for Biomimetic Construction of Calcium Phosphate Mineral Shells on Microbial Cells

期刊

ACS SUSTAINABLE CHEMISTRY & ENGINEERING
卷 9, 期 29, 页码 9854-9860

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.1c02485

关键词

biomimetic construction; artificial mineral shell; Acetobacter xylinum; nanocellulose; calcium phosphate

资金

  1. National Natural Science Foundation of China [51803092, 51873087, 81801839]
  2. Natural Science Foundation of China Jiangsu Province [BK20180490]
  3. Fundamental Research Funds for the Central Universities [30920130121001]
  4. Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD, China)
  5. Advanced Catalysis and Green Manufacturing Collaborative Innovation Center (Changzhou University)
  6. program for Science and Technology Innovative Research Team in Universities of Jiangsu Province, China

向作者/读者索取更多资源

The study demonstrates a microbial in situ mineralization strategy using Acetobacter xylinum to construct functional mineral shells on cell surfaces, which can serve as ideal shields for cells to resist natural toxins.
Biomimetic construction of functional shells on cells is highly important in modifying an engineered cell surface. Herein, we report a microbial in situ mineralization strategy using Acetobacter xylinum as a model strain to explore the interactions between cell metabolism and calcium phosphate crystallization. Mineral precipitation has been observed outside the cell walls during the metabolism of bacterial cellulose. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) results reveal that in situ mineralization of calcium phosphate can be realized on a microorganism surface by simply treatment of simulated body fluid. The cell survival test reveals that the prepared artificial mineral shell can be an ideal shield for cells to resist natural toxins without disturbing their normal physiological metabolism. This finding provides a robust route to in situ biomimetic construction of living cells with functional mineral shells during their metabolic process without modifying the surface characteristic.

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