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Hong Joo Kim et al.
NATURE (2013)
An exploratory study on STX6, MOBP, MAPT, and EIF2AK3 and late-onset Alzheimer's disease
Qiu-Yan Liu et al.
NEUROBIOLOGY OF AGING (2013)
Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products
Quentin Defenouillere et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in Drosophila melanogaster
Peter Nagy et al.
PLOS GENETICS (2013)
Pharmacological brake-release of mRNA translation enhances cognitive memory
Carmela Sidrauski et al.
ELIFE (2013)
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome
Rati Verma et al.
ELIFE (2013)
Adult-Onset Vanishing White Matter Disease Due to a Novel EIF2B3 Mutation
Roberta La Piana et al.
ARCHIVES OF NEUROLOGY (2012)
Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis
Rajasekhar N. V. S. Suragani et al.
BLOOD (2012)
Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals
Hidenori Tani et al.
GENOME RESEARCH (2012)
Identification of Residues That Underpin Interactions within the Eukaryotic Initiation Factor (eIF2) 2B Complex
Xuemin Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth
Lori S. Hart et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
Jeffrey M. Axten et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
elF2γ Mutation that Disrupts elF2 Complex Integrity Links Intellectual Disability to Impaired Translation Initiation
Guntram Borck et al.
MOLECULAR CELL (2012)
A unifying model for mTORC1-mediated regulation of mRNA translation
Carson C. Thoreen et al.
NATURE (2012)
Sustained translational repression by eIF2α-P mediates prion neurodegeneration
Julie A. Moreno et al.
NATURE (2012)
The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes
Thomas E. Dever et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)
Wolcott-Rallison Syndrome Due to a Novel Mutation (R491X) in EIF2AK3 Gene
Ercan Mihci et al.
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY (2012)
Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition
Ping Jun Zhu et al.
CELL (2011)
Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase
Nao Hosoda et al.
EMBO JOURNAL (2011)
Translational coregulation of 5′TOP mRNAs by TIA-1 and TIAR
Christian Kroun Damgaard et al.
GENES & DEVELOPMENT (2011)
Severity of Vanishing White Matter Disease Does Not Correlate with Deficits in eIF2B Activity or the Integrity of eIF2B Complexes
Rui Liu et al.
HUMAN MUTATION (2011)
Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to Enhance CHOP Translation
Lakshmi Reddy Palam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Vanishing White Matter Disease Associated With Ptosis and Myoclonic Seizures
Suvasini Sharma et al.
JOURNAL OF CHILD NEUROLOGY (2011)
Functional analysis of recently identified mutations in eukaryotic translation initiation factor 2Bε (eIF2Bε) identified in Chinese patients with vanishing white matter disease
Xuerong Leng et al.
JOURNAL OF HUMAN GENETICS (2011)
Heparin Activates PKR by Inducing Dimerization
Eric Anderson et al.
JOURNAL OF MOLECULAR BIOLOGY (2011)
Defective Glial Maturation in Vanishing White Matter Disease
Marianna Bugiani et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2011)
A novel EIF2AK3 mutation leading to Wolcott-Rallison syndrome in a Chinese child
Yanmei Sang et al.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2011)
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy
Guenter U. Hoeglinger et al.
NATURE GENETICS (2011)
Adult-onset leukoencephalopathies with vanishing white matter with novel missense mutations in EIF2B2, EIF2B3, and EIF2B5
Takashi Matsukawa et al.
NEUROGENETICS (2011)
Two novel mutations in the EIF2AK3 gene in children with Wolcott-Rallison syndrome
Andre F. Reis et al.
PEDIATRIC DIABETES (2011)
Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis
Pavel Tsaytler et al.
SCIENCE (2011)
Role of a ribosome-associated E3 ubiquitin ligase in protein quality control
Mario H. Bengtson et al.
NATURE (2010)
Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS
Jane O. Johnson et al.
NEURON (2010)
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage
E. Bobrovnikova-Marjon et al.
ONCOGENE (2010)
Wolcott-Rallison syndrome
Cecile Julier et al.
ORPHANET JOURNAL OF RARE DISEASES (2010)
The role of AUF1 in regulated mRNA decay
Frances M. Gratacos et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA (2010)
Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease
Graham D. Pavitt et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2009)
Natural history of adult-onset eIF2B-related disorders: a multi-centric survey of 16 cases
Pierre Labauge et al.
BRAIN (2009)
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
Nahum Sonenberg et al.
CELL (2009)
An Upstream Open Reading Frame Regulates Translation of GADD34 during Cellular Stresses That Induce eIF2α Phosphorylation
Yun-Young Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae
Tomas Grousl et al.
JOURNAL OF CELL SCIENCE (2009)
Identification of novel EIF2B mutations in Chinese patients with vanishing white matter disease
Ye Wu et al.
JOURNAL OF HUMAN GENETICS (2009)
A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation
Patrick S. Tarpey et al.
NATURE GENETICS (2009)
SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells
Andrea B. Eberle et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration
Jessie Chu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development
Heather P. Harding et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Specific and global regulation of mRNA stability during osmotic stress in Saccharomyces cerevisiae
Lorena Romero-Santacreu et al.
RNA (2009)
Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
Caroline Vance et al.
SCIENCE (2009)
A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity
Gorben P. Pijlman et al.
CELL HOST & MICROBE (2008)
The ovarioleukodystrophy
Stephane Mathis et al.
CLINICAL NEUROLOGY AND NEUROSURGERY (2008)
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways
Pavel V. Ivanov et al.
EMBO JOURNAL (2008)
Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells
Dinghai Zheng et al.
JOURNAL OF CELL BIOLOGY (2008)
PERK Is Essential for Neonatal Skeletal Development to Regulate Osteoblast Proliferation and Differentiation
Jianwen Wei et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2008)
The role of PACT in mediating gene induction, PKR activation, and apoptosis in response to diverse stimuli
Joao T. Marques et al.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2008)
Mechanism of PKR activation by dsRNA
Peter A. Lemaire et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology:: a genetic and histopathological analysis
Vivianna M. Van Deerlin et al.
LANCET NEUROLOGY (2008)
The Th2 transcription factor c-Maf inhibits IL-12p35 gene expression in activated macrophages by targeting NF-κB nuclear translocation
Yoichiro Homma et al.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2007)
PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice
Kaori Iida et al.
BMC CELL BIOLOGY (2007)
The decapping activator Lsm1p-7p-Pat1p complex has the intrinsic ability to distinguish between oligoadenylated and polyadenylated RNAs
Ashis Chowdhury et al.
RNA (2007)
Accumulation of polyadenylated mRNA, Pab1, eIF4E, and eIF4G with P-bodies in Saccharomyces cerevisiae
Muriel Brengues et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
P-body formation is a consequence, not the cause, of RNA-mediated gene silencing
Ana Eulalio et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
PERK EIF2AK3 control of pancreatic β cell differentiation and proliferation is required for postnatal glucose homeostasis
Wei Zhang et al.
CELL METABOLISM (2006)
ZBP1 regulates mRNA stability during cellular stress
Nadine Stoehr et al.
JOURNAL OF CELL BIOLOGY (2006)
Translation-independent inhibition of mRNA deadenylation during stress in Saccharomyces cerevisiae
Valerie Hilgers et al.
RNA (2006)
Global translational responses to oxidative stress impact upon multiple levels of protein synthesis
Daniel Shenton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Yeast transcripts cleaved by an internal ribozyme provide new insight into the role of the cap and poly(A) tail in translation and mRNA decay
Stacie Meaux et al.
RNA (2006)
Expression of the HXT13, HXT15 and HXT17 genes in Saccharomyces cerevisiae and stabilization of the HXT1 gene transcript by sugar-induced osmotic stress
BW Greatrix et al.
CURRENT GENETICS (2006)
Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation
MK Doma et al.
NATURE (2006)
Regulation of protein synthesis in lymphoblasts from vanishing white matter patients
B van Kollenburg et al.
NEUROBIOLOGY OF DISEASE (2006)
Inhibition of mRNA deadenylation and degradation by different types of cell stress
G Gowrishankar et al.
BIOLOGICAL CHEMISTRY (2006)
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
I Kashima et al.
GENES & DEVELOPMENT (2006)
Inhibition of mRNA deadenylation and degradation by ultraviolet light
G Gowrishankar et al.
BIOLOGICAL CHEMISTRY (2005)
Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies
M Brengues et al.
SCIENCE (2005)
Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients
L Kantor et al.
HUMAN GENETICS (2005)
Stress granules and processing bodies are dynamically linked sites of mRNP remodeling
N Kedersha et al.
JOURNAL OF CELL BIOLOGY (2005)
Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure
E McEwen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Processing bodies require RNA for assembly and contain nontranslating mRNAs
D Teixeira et al.
RNA (2005)
EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy
J Dietrich et al.
NATURE MEDICINE (2005)
A selective inhibitor-of eIF2α dephosphorylation protects cells from ER stress
M Boyce et al.
SCIENCE (2005)
Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein
GDJ Watts et al.
NATURE GENETICS (2004)
Mutations linked to Leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways
W Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Inhibition of 5′ to 3′ mRNA degradation under stress conditions in Saccharomyces cerevisiae:: from GCN4 to MET16
L Benard
RNA (2004)
mTOR-dependent activation of the transcription factor TIMA links rRNA synthesis to nutrient availability
C Mayer et al.
GENES & DEVELOPMENT (2004)
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
KM Vattem et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Global mRNA stabilization preferentially linked to translational repression during the endoplasmic reticulum stress response
T Kawai et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
SJ Marciniak et al.
GENES & DEVELOPMENT (2004)
Differential activation of eIF2 kinases in response to cellular stresses in Schizosaccharomyces pombe
K Zhan et al.
GENETICS (2004)
Wolcott-Rallison syndrome -: Clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity
V Senée et al.
DIABETES (2004)
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
J Deng et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Inhibition of a constitutive translation initiation factor 2α phosphatase CReP, promotes survival of stressed cells
C Jousse et al.
JOURNAL OF CELL BIOLOGY (2003)
Small molecule inhibitors of the RNA-dependent protein kinase
NV Jammi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
PERK eIF2α kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver
YL Li et al.
ENDOCRINOLOGY (2003)
Ovarian failure related to eukaryotic initiation factor 2B mutations
A Fogli et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2003)
Decapping and decay of messenger RNA occur in cytoplasmic processing bodies
U Sheth et al.
SCIENCE (2003)
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
HP Harding et al.
MOLECULAR CELL (2003)
Evidence for general stabilization of mRNAs in response to UV light
F Bollig et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)
The GCN2 eIF2α kinase is required for adaptation to amino acid deprivation in mice
PC Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Activation of GCN2 in UV-irradiated cells inhibits translation
J Deng et al.
CURRENT BIOLOGY (2002)
The PERK eukaryotic initiation factor 2α kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas
PC Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulum
SY Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2
HF Qiu et al.
GENES & DEVELOPMENT (2002)
MEHMO (Mental retardation, Epileptic seizures, Hypogenitalism, Microcephaly, Obesity): a new X-linked mitochondrial disorder
E Leshinsky-Silver et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2002)
Exosome-mediated recognition and degradation of mRNAs lacking a termination codon
A van Hoof et al.
SCIENCE (2002)
An mRNA surveillance mechanism that eliminates transcripts lacking termination codons
PA Frischmeyer et al.
SCIENCE (2002)
Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter
MS van der Knaap et al.
ANNALS OF NEUROLOGY (2002)
Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules
N Kedersha et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
Heme-regulated eIF2α kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency
AP Han et al.
EMBO JOURNAL (2001)
Translation initiation control by heme-regulated eukaryotic initiation factor 2α kinase in erythroid cells under cytoplasmic stresses
LR Lu et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter
PAJ Leegwater et al.
NATURE GENETICS (2001)
AU binding proteins recruit the exosome to degrade ARE-containing mRNAs
CY Chen et al.
CELL (2001)
The protein kinase Gcn2p mediates sodium toxicity in yeast
A Goossens et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Diabetes mellitus and exocrine pancreatic dysfunction in Perk-/- mice reveals a role for translational control in secretory cell survival
HP Harding et al.
MOLECULAR CELL (2001)
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α
I Novoa et al.
JOURNAL OF CELL BIOLOGY (2001)
The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation
H Qiu et al.
EMBO JOURNAL (2001)
Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules
N Kedersha et al.
JOURNAL OF CELL BIOLOGY (2000)
Synthesis of the translational apparatus is regulated at the translational level
O Meyuhas
EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)
Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-Binding domain
JS Dong et al.
MOLECULAR CELL (2000)
EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome
M Delépine et al.
NATURE GENETICS (2000)
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
A Bertolotti et al.
NATURE CELL BIOLOGY (2000)
Glucose starvation induces a drastic reduction in the rates of both transcription and degradation of mRNA in yeast
G Jona et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2000)
UV-induced stabilization of c-fos and other short-lived mRNAs
C Blattner et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Glucose depletion rapidly inhibits translation initiation in yeast
MP Ashe et al.
MOLECULAR BIOLOGY OF THE CELL (2000)
HuR regulates p21 mRNA stabilization by UV light
WG Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
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