4.7 Review

The Protein Toxins Ricin and Shiga Toxin as Tools to Explore Cellular Mechanisms of Internalization and Intracellular Transport

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus

Anne Berit Dyve Lingelem et al.

Summary: DAG and PA are important second messengers involved in regulating membrane transport, and their modulation can influence retrograde ricin transport to the Golgi apparatus. Inhibitors of DAG kinase and phospholipase D impact endosome morphology and alter the presence of proteins regulating retrograde transport within tubular structures. Lipidomic analysis reveals unexpected increases in DAG levels with PLD inhibitor treatment, emphasizing the importance of lipidomic analysis when using lipid metabolism inhibitors.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Biochemistry & Molecular Biology

The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa

Annette Brandel et al.

Summary: The opportunistic pathogen Pseudomonas aeruginosa has gained importance due to its antibiotic resistance. The interaction between bacterial lectin LecA and host cell membrane components plays a crucial role in bacterial engulfment and invasion. Flotillins and GPI-anchored protein CD59 influence bacterial invasion by facilitating efficient uptake of the pathogen.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Cell Biology

Caveolae: Mechanosensing and mechanotransduction devices linking membrane trafficking to mechanoadaptation

Miguel A. Del Pozo et al.

Summary: Caveolae are nanodomains with specific lipid and protein composition that flatten upon increased plasma membrane tension, critical for force sensing and accommodation in mechanically challenged tissues. They play a key role in protecting cells from mechanical stress damage and are highly plastic structures that interact with mechanotransduction pathways, with components capable of translocating to the nucleus to convey stress information. Additionally, caveolae regulate membrane traffic in response to environmental mechanical forces, highlighting their relevance in mechanoadaption in different physiological and pathological processes.

CURRENT OPINION IN CELL BIOLOGY (2021)

Review Food Science & Technology

Shiga Toxins: An Update on Host Factors and Biomedical Applications

Yang Liu et al.

Summary: Shiga toxins are classic bacterial toxins associated with Shigella dysenteriae and enterohemorrhagic Escherichia coli, leading to life-threatening complications such as hemolytic uremic syndrome. The lack of toxin inhibitors and effective treatments exacerbates the threat posed by Stxs.

TOXINS (2021)

Review Cell Biology

Unconventional endocytic mechanisms

Henri-Francois Renard et al.

Summary: Endocytosis is a crucial mechanism for cellular uptake, also utilized by viruses, toxins, and bacteria for cell invasion. Besides the canonical clathrin-mediated pathway, there are various clathrin-independent mechanisms for internalizing specific cargoes and supporting cellular functions.

CURRENT OPINION IN CELL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Phosphatidylserine is critical for vesicle fission during clathrin-mediated endocytosis

Kelly Varga et al.

JOURNAL OF NEUROCHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Functional dissection of the retrograde Shiga toxin trafficking inhibitor Retro-2

Alison Forrester et al.

NATURE CHEMICAL BIOLOGY (2020)

Review Pharmacology & Pharmacy

An emerging focus on lipids in extracellular vesicles

Tore Skotland et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Review Oncology

The role of lipid species in membranes and cancer-related changes

Tore Skotland et al.

CANCER AND METASTASIS REVIEWS (2020)

Article Biochemistry & Molecular Biology

Roles of endogenous ether lipids and associated PUFAs in the regulation of ion channels and their relevance for disease

Delphine Fontaine et al.

JOURNAL OF LIPID RESEARCH (2020)

Review Cell Biology

Recognising the signals for endosomal trafficking

Saroja Weeratunga et al.

CURRENT OPINION IN CELL BIOLOGY (2020)

Review Cell Biology

Caveolae: Formation, dynamics, and function

Robert G. Parton et al.

CURRENT OPINION IN CELL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Molecular mechanism of Fast Endophilin-Mediated Endocytosis

Alessandra Casamento et al.

BIOCHEMICAL JOURNAL (2020)

Article Cell Biology

Evolving models for assembling and shaping clathrin-coated pits

Zhiming Chen et al.

JOURNAL OF CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway

Noemi Jimenez-Rojo et al.

CURRENT BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Targeting Receptors on Cancer Cells with Protein Toxins

Antonella Antignani et al.

BIOMOLECULES (2020)

Article Cell Biology

Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons

Nils Rother et al.

CELL REPORTS MEDICINE (2020)

Review Nanoscience & Nanotechnology

Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy

Xiaowei Wang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Review Biochemistry & Molecular Biology

On the road to unraveling the molecular functions of ether lipids

Noemi Jimenez-Rojo et al.

FEBS LETTERS (2019)

Article Multidisciplinary Sciences

The role of PS 18:0/18:1 in membrane function

Tore Skotland et al.

NATURE COMMUNICATIONS (2019)

Review Food Science & Technology

Intracellular Transport and Cytotoxicity of the Protein Toxin Ricin

Natalia Sowa-Rogozinska et al.

TOXINS (2019)

Article Chemistry, Multidisciplinary

Shiga Toxin Induces Lipid Compression: A Mechanism for Generating Membrane Curvature

Erik B. Watkins et al.

NANO LETTERS (2019)

Review Cell Biology

Directing Traffic: Regulation of COPI Transport by Post-translational Modifications

Peter M. Luo et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Review Cell Biology

Structural and functional roles of ether lipids

John M. Dean et al.

PROTEIN & CELL (2018)

Article Biochemistry & Molecular Biology

Lysophospholipids Facilitate COPII Vesicle Formation

Alejandro Melero et al.

CURRENT BIOLOGY (2018)

Review Cell Biology

Mechanisms of cellular cholesterol compartmentalization: recent insights

Elina Ikonen

CURRENT OPINION IN CELL BIOLOGY (2018)

Review Cell Biology

Clathrin-independent endocytosis: an increasing degree of complexity

Kirsten Sandvig et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2018)

Article Cell Biology

Formation of COPI-coated vesicles at a glance

Eric C. Arakel et al.

JOURNAL OF CELL SCIENCE (2018)

Review Biochemistry & Molecular Biology

Lipid transfer proteins rectify inter-organelle flux and accurately deliver lipids at membrane contact sites

Kentaro Hanada

JOURNAL OF LIPID RESEARCH (2018)

Review Cell Biology

Understanding the diversity of membrane lipid composition

Takeshi Harayama et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Cell Biology

Mechanisms of clathrin-mediated endocytosis

Marko Kaksonen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Microbiology

GM1 ganglioside-independent intoxication by Cholera toxin

Jakob Cervin et al.

PLOS PATHOGENS (2018)

Article Pharmacology & Pharmacy

Moxetumomab Pasudotox: First Global Approval

Sohita Dhillon

Review Biochemistry & Molecular Biology

Lipids in exosomes: Current knowledge and the way forward

Tore Skotland et al.

PROGRESS IN LIPID RESEARCH (2017)

Review Food Science & Technology

Protection against Shiga Toxins

Simona Kavaliauskiene et al.

TOXINS (2017)

Review Food Science & Technology

Shiga ToxinA Model for Glycolipid-Dependent and Lectin-Driven Endocytosis

Ludger Johannes

TOXINS (2017)

Review Cell Biology

Interleaf let Coupling, Pinning, and Leaflet Asymmetry-Major Players in Plasma Membrane Nanodomain Formation

Toyoshi Fujimoto et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Cross-linking of glycosphingolipids at the plasma membrane: consequences for intracellular signaling and traffic

Tove Irene Klokk et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Article Biochemistry & Molecular Biology

Inhibition of Rab prenylation by statins induces cellular glycosphingolipid remodeling

Beth Binnington et al.

GLYCOBIOLOGY (2016)

Review Biochemistry & Molecular Biology

Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling

Taroh Kinoshita et al.

JOURNAL OF LIPID RESEARCH (2016)

Article Biochemistry & Molecular Biology

The biophysical properties of ethanolamine plasmalogens revealed by atomistic molecular dynamics simulations

Tomasz Rog et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2016)

Article Biochemistry & Molecular Biology

Interdigitation of long-chain sphingomyelin induces coupling of membrane leaflets in a cholesterol dependent manner

Tomasz Rog et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2016)

Review Oncology

How We Read Oncologic FDG PET/CT

Michael S. Hofman et al.

CANCER IMAGING (2016)

Article Multidisciplinary Sciences

Addition of lysophospholipids with large head groups to cells inhibits Shiga toxin binding

Ieva Ailte et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Novel actions of 2-deoxy-D-glucose: protection against Shiga toxins and changes in cellular lipids

Simona Kavaliauskiene et al.

BIOCHEMICAL JOURNAL (2015)

Article Biochemistry & Molecular Biology

Lateral organization, bilayer asymmetry, and inter-leaflet coupling of biological membranes

Jonathan D. Nickels et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2015)

Article Multidisciplinary Sciences

Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour

Mathieu Frechin et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

The Ether Lipid Precursor Hexadecylglycerol Stimulates the Release and Changes the Composition of Exosomes Derived from PC-3 Cells

Santosh Phuyal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Review Biochemistry & Molecular Biology

Ceramide synthases as potential targets for therapeutic intervention in human diseases

Joo-Won Park et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2014)

Article Biochemistry & Molecular Biology

Cell density-induced changes in lipid composition and intracellular trafficking

Simona Kavaliauskiene et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2014)

Article Biochemistry & Molecular Biology

The ether lipid precursor hexadecylglycerol protects against Shiga toxins

Jonas Bergan et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2014)

Review Biochemistry & Molecular Biology

Cholesterol, sphingolipids, and glycolipids: What do we know about their role in raft-like membranes?

Tomasz Rog et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2014)

Review Biochemistry & Molecular Biology

Lipid requirements for entry of protein toxins into cells

Kirsten Sandvig et al.

PROGRESS IN LIPID RESEARCH (2014)

Article Biochemistry & Molecular Biology

Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate Clathrin-Independent Endocytosis

Natasha Chaudhary et al.

PLOS BIOLOGY (2014)

Article Biochemistry & Molecular Biology

A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility

Michael C. Bassik et al.

Review Cell Biology

Retrograde transport of protein toxins through the Golgi apparatus

Kirsten Sandvig et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Functions of plasmalogen lipids in health and disease

Nancy E. Braverman et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Article Multidisciplinary Sciences

Molecular recognition of a single sphingolipid species by a protein's transmembrane domain

F. -Xabier Contreras et al.

NATURE (2012)

Article Multidisciplinary Sciences

Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis

Somshuvra Mukhopadhyay et al.

SCIENCE (2012)

Review Pharmacology & Pharmacy

Shiga toxins

Jonas Bergan et al.

TOXICON (2012)

Review Biochemistry & Molecular Biology

High throughput quantitative molecular lipidomics

Hye R. Jung et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2011)

Review Chemistry, Multidisciplinary

Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

Alfred H. Merrill

CHEMICAL REVIEWS (2011)

Article Biochemistry & Molecular Biology

Plasmalogens the neglected regulatory and scavenging lipid species

Stefan Wallner et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2011)

Article Cell Biology

Genome-Wide RNAi Screens Identify Genes Required for Ricin and PE Intoxications

Dimitri Moreau et al.

DEVELOPMENTAL CELL (2011)

Article Cell Biology

Actin dynamics counteract membrane tension during clathrin-mediated endocytosis

Steeve Boulant et al.

NATURE CELL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Cholesterol modulates glycolipid conformation and receptor activity

Daniel Lingwood et al.

NATURE CHEMICAL BIOLOGY (2011)

Review Biotechnology & Applied Microbiology

Shiga toxin and its use in targeted cancer therapy and imaging

Nikolai Engedal et al.

MICROBIAL BIOTECHNOLOGY (2011)

Article Biochemistry & Molecular Biology

Inhibition of Retrograde Transport Protects Mice from Lethal Ricin Challenge

Bahne Stechmann et al.

Review Biochemistry & Molecular Biology

New aspects of the regulation of glycosphingolipid receptor function

Clifford A. Lingwood et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2010)

Article Biochemistry & Molecular Biology

Co-regulation of Caveolar and Cdc42-dependent Fluid Phase Endocytosis by Phosphocaveolin-1

Zhi-Jie Cheng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Editorial Material Cell Biology

Revisiting caveolin trafficking: the end of the caveosome

Robert G. Parton et al.

JOURNAL OF CELL BIOLOGY (2010)

Review Microbiology

Shiga toxins - from cell biology to biomedical applications

Ludger Johannes et al.

NATURE REVIEWS MICROBIOLOGY (2010)

Review Cell Biology

Lipidomics: coming to grips with lipid diversity

Andrej Shevchenko et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Multidisciplinary Sciences

Shiga Toxin Increases Formation of Clathrin-Coated Pits through Syk Kinase

Audrun Utskarpen et al.

PLOS ONE (2010)

Article Cell Biology

The mitogen-activated protein kinase p38 links Shiga toxin-dependent signaling and trafficking

Sebastien Walchli et al.

MOLECULAR BIOLOGY OF THE CELL (2008)

Review Cell Biology

Membrane lipids: where they are and how they behave

Gerrit van Meer et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Polyunsaturated fatty acids regulate Shiga toxin transport

Bjorn Spilsberg et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Multidisciplinary Sciences

Shiga toxin induces tubular membrane invaginations for its uptake into cells

Winfried Roemer et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

SNX1 and SNX2 mediate retrograde transport of Shiga toxin

Audrun Utskarpen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Cell Biology

The retromer complex and clathrin define an early endosomal retrograde exit site

Vincent Popoff et al.

JOURNAL OF CELL SCIENCE (2007)

Article Immunology

Induction of cell signaling events by the cholera toxin B subunit in antigen-presenting cells

Aletta C. Schnitzler et al.

INFECTION AND IMMUNITY (2007)

Article Biochemistry & Molecular Biology

Structures and physiological roles of 13 integral lipids of bovine heart cytochrome c oxidase

Kyoko Shinzawa-Itoh et al.

EMBO JOURNAL (2007)

Article Chemistry, Multidisciplinary

Shiga toxin-mediated retrograde delivery of a topoisomerase I inhibitor prodrug

Abdessamad El Alaoui et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)

Article Biochemistry & Molecular Biology

Functionally different pools of Shiga toxin receptor, globotriaosyl ceramide, in HeLa cells

Thomas Falguieres et al.

FEBS JOURNAL (2006)

Review Biochemistry & Molecular Biology

Phosphatidic acid- and phosphatidylserine-binding proteins

Catherine L. Stace et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2006)

Article Cell Biology

EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol

M Slominska-Wojewodzka et al.

MOLECULAR BIOLOGY OF THE CELL (2006)

Article Cell Biology

Shiga toxin regulates its entry in a syk-dependent manner

SU Lauvrak et al.

MOLECULAR BIOLOGY OF THE CELL (2006)

Article Biochemistry & Molecular Biology

The A-subunit of surface-bound Shiga toxin stimulates clathrin-dependent uptake of the toxin

ML Torgersen et al.

FEBS JOURNAL (2005)

Review Biochemistry & Molecular Biology

Delivery into cells: lessons learned from plant and bacterial toxins

K Sandvig et al.

GENE THERAPY (2005)

Article Cell Biology

Role of lipids in the retrograde pathway of ricin intoxication

B Spillsberg et al.

TRAFFIC (2003)

Article Cell Biology

Rapid cycling of lipid raft markers between the cell surface and Golgi complex

BJ Nichols et al.

JOURNAL OF CELL BIOLOGY (2001)