4.1 Article

Expression of M3 acetylcholine receptor in asthmatic mice and bronchial airway remodeling prediction

期刊

GENETICS AND MOLECULAR RESEARCH
卷 15, 期 3, 页码 -

出版社

FUNPEC-EDITORA
DOI: 10.4238/gmr.15038805

关键词

Asthma; M-3 acetylcholine receptor; Airway remodeling

资金

  1. Changchun Science and Technology Bureau [12ZP32]

向作者/读者索取更多资源

This study aimed to investigate the role of M-3 acetylcholine receptor (M-3-AChR) expression in airway remodeling. Additionally, we aimed to evaluate the effects of ipratropium bromide solution inhaled in an early phase of asthma on airway remodeling in ovalbumin (OVA)-sensitized and challenged mice. Thirty BALB/c mice were divided into three groups, namely, control group (saline sensitized/challenged mice), asthma group (OVA sensitized/challenged mice), and treatment group (OVA sensitized/challenged mice treated by ipratropium bromide). Pathological changes were detected by histological staining in the bronchopulmonary tissue of mice. WAt/Pbm (the airway wall area /basement membrane perimeter) ratio of the asthma group (25.37 +/- 4.25) increased significantly (P < 0.05) when compared with that of the control (12.89 +/- 1.71) and treatment group (15.82 +/- 2.91). WAm/Pbm (smooth muscle wall area / basement membrane perimeter) ratio of the asthma group (7.58 +/- 2.16) increased significantly (P < 0.05) when compared with that of the control (2.55 +/- 0.72) and treatment group (3.36 +/- 1.69). M-3-AChR concentration increased in the treatment group (29.24 +/- 3.59) and was significantly different (P < 0.05) from that of the control group (25.50 +/- 1.83). During asthma treatment, SAMA can alleviate airway remodeling in murine model by lessening the thickness of bronchial walls and inhibiting the proliferation of smooth muscle cells. There were no obvious changes in M-3-AChR density in the murine model of asthma characterized by airway remodeling. However, ipratropium bromide may up-regulate the expression of M-3-AChR in bronchial walls of asthmatic murine model.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.1
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据