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CANCER LETTERS (2015)
Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism
Samantha J. Mentch et al.
CELL METABOLISM (2015)
s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways
Wei Ding et al.
CELL METABOLISM (2015)
Hypoxia Induces Production of L-2-Hydroxyglutarate
Andrew M. Intlekofer et al.
CELL METABOLISM (2015)
Acetyl Coenzyme A: A Central Metabolite and Second Messenger
Federico Pietrocola et al.
CELL METABOLISM (2015)
Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress
William M. Oldham et al.
CELL METABOLISM (2015)
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions
Linchong Sun et al.
CELL RESEARCH (2015)
Sirtuins in Epigenetic Regulation
Hui Jing et al.
CHEMICAL REVIEWS (2015)
Epigenetics and Metabolism
Samuel T. Keating et al.
CIRCULATION RESEARCH (2015)
Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation
Erin E. Witalison et al.
CURRENT DRUG TARGETS (2015)
Histone demethylases in chromatin biology and beyond
Emilia Dimitrova et al.
EMBO REPORTS (2015)
Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice With Severe Acute Pancreatitis
Mohammed Merza et al.
GASTROENTEROLOGY (2015)
Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?
Wen Zhang et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2015)
A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors
Quincy Siu-Chung Chu et al.
INVESTIGATIONAL NEW DRUGS (2015)
Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation
Matthew D. Hirschey et al.
MOLECULAR & CELLULAR PROTEOMICS (2015)
NADP+-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance
Feng Li et al.
MOLECULAR CELL (2015)
Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism
Shanshan Li et al.
MOLECULAR CELL (2015)
Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation
Ke Liu et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Targeting histone lysine methylation in cancer
John McGrath et al.
PHARMACOLOGY & THERAPEUTICS (2015)
NAD+ in aging, metabolism, and neurodegeneration
Eric Verdin
SCIENCE (2015)
Dysregulated metabolism contributes to oncogenesis
Matthew D. Hirschey et al.
SEMINARS IN CANCER BIOLOGY (2015)
D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2
An-Ping Lin et al.
NATURE COMMUNICATIONS (2015)
Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite D-2-Hydroxyglutarate
Jing Fan et al.
ACS CHEMICAL BIOLOGY (2015)
Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice
Jason S. Knight et al.
ANNALS OF THE RHEUMATIC DISEASES (2015)
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
Bryce W. Carey et al.
NATURE (2015)
A Comprehensive View of the Epigenetic Landscape. Part II: Histone Post-translational Modification, Nucleosome Level, and Chromatin Regulation by ncRNAs
Anna Sadakierska-Chudy et al.
NEUROTOXICITY RESEARCH (2015)
O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling
Jianhua Shi et al.
SCIENTIFIC REPORTS (2015)
Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization
Abhishek K. Jha et al.
IMMUNITY (2015)
Efficacy and Safety of ETC-1002, a Novel Investigational Low-Density Lipoprotein-Cholesterol-Lowering Therapy for the Treatment of Patients With Hypercholesterolemia and Type 2 Diabetes Mellitus
Maria J. Gutierrez et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)
Towards understanding methyllysine readout
Catherine A. Musselman et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2014)
Serine Deprivation Enhances Antineoplastic Activity of Biguanides
Simon-Pierre Gravel et al.
CANCER RESEARCH (2014)
A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation
Gopinath Sutendra et al.
CELL (2014)
A Mitochondrial Expatriate: Nuclear Pyruvate Dehydrogenase
Vincent C. J. de Boer et al.
CELL (2014)
Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases
Tomoyuki Mashimo et al.
CELL (2014)
Acetate Dependence of Tumors
Sarah A. Comerford et al.
CELL (2014)
Acetate Fuels the Cancer Engine
Costas A. Lyssiotis et al.
CELL (2014)
Nutrient Regulation of Signaling, Transcription, and Cell Physiology by O-GlcNAcylation
Stephan Hardiville et al.
CELL METABOLISM (2014)
Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation
Joyce V. Lee et al.
CELL METABOLISM (2014)
Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan
Tobias Eisenberg et al.
CELL METABOLISM (2014)
LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase
Sergey Filippov et al.
CURRENT OPINION IN LIPIDOLOGY (2014)
β-hydroxybutyrate: Much more than a metabolite
John C. Newman et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2014)
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors
E. M. Dunbar et al.
INVESTIGATIONAL NEW DRUGS (2014)
Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal
Tingting Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
The Pyruvate Dehydrogenase Complexes: Structure-based Function and Regulation
Mulchand S. Patel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
O-GlcNAc and the Epigenetic Regulation of Gene Expression
Brian A. Lewis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Differential Regulation of the Ten-Eleven Translocation (TET) Family of Dioxygenases by O-Linked β-N-Acetylglucosamine Transferase (OGT)
Qiao Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
c-Myc Programs Fatty Acid Metabolism and Dictates Acetyl-CoA Abundance and Fate
Lia R. Edmunds et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma
Sarah K. Knutson et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth
Changliang Shan et al.
MOLECULAR CELL (2014)
O-GlcNAcylation Regulates Cancer Metabolism and Survival Stress Signaling via Regulation of the HIF-1 Pathway
Christina M. Ferrer et al.
MOLECULAR CELL (2014)
Vimentin Is Involved in Peptidylarginine Deiminase 2-Induced Apoptosis of Activated Jurkat Cells
Pei-Chen Hsu et al.
MOLECULES AND CELLS (2014)
Citrullination regulates pluripotency and histone H1 binding to chromatin
Maria A. Christophorou et al.
NATURE (2014)
Caloric restriction mimetics: towards a molecular definition
Frank Madeo et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
Katrina J. Falkenberg et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
The growing landscape of lysine acetylation links metabolism and cell signalling
Chunaram Choudhary et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma
Jun Pan et al.
ONCOLOGY REPORTS (2014)
Epigenetic targets and drug discovery Part 1: Histone methylation
Yanli Liu et al.
PHARMACOLOGY & THERAPEUTICS (2014)
O-GlcNAcylation regulates EZH2 protein stability and function
Chi-Shuen Chu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate
Zigmund Luka et al.
PROTEIN SCIENCE (2014)
Ketone bodies as signaling metabolites
John C. Newman et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2014)
L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer
Eun-Hee Shim et al.
CANCER DISCOVERY (2014)
Necrosis-Driven Systemic Immune Response Alters SAM Metabolism through the FOXO-GNMT Axis
Fumiaki Obata et al.
CELL REPORTS (2014)
O-GlcNAcylation, an epigenetic mark. Focus on the histone code, TET family proteins, and polycomb group proteins
Vanessa Dehennaut et al.
FRONTIERS IN ENDOCRINOLOGY (2014)
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
Scott R. Daigle et al.
BLOOD (2013)
R-2-Hydroxyglutarate as the Key Effector of IDH Mutations Promoting Oncogenesis
Dan Ye et al.
CANCER CELL (2013)
Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
Sebastian Bender et al.
CANCER CELL (2013)
Influence of Metabolism on Epigenetics and Disease
William G. Kaelin et al.
CELL (2013)
SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks
Matthew J. Rardin et al.
CELL METABOLISM (2013)
O-GlcNAc Signaling Entrains the Circadian Clock by Inhibiting BMAL1/CLOCK Ubiquitination
Min-Dian Li et al.
CELL METABOLISM (2013)
TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS
Rachel Deplus et al.
EMBO JOURNAL (2013)
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
Julie-Aurore Losman et al.
GENES & DEVELOPMENT (2013)
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
Kui-Ming Chan et al.
GENES & DEVELOPMENT (2013)
Epigenetic Switching by the Metabolism-sensing Factors in the Generation of Orexin Neurons from Mouse Embryonic Stem Cells
Koji Hayakawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site
Sivakama S. Bharathi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Ten-Eleven Translocation 1 (Tet1) Is Regulated by O-Linked N-Acetylglucosamine Transferase (Ogt) for Target Gene Repression in Mouse Embryonic Stem Cells
Feng-Tao Shi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Methionine Adenosyltransferase II-dependent Histone H3K9 Methylation at the COX-2 Gene Locus
Yohei Kera et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins
Jessica L. Feldman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Efficacy and Safety of a Novel Dual Modulator of Adenosine Triphosphate-Citrate Lyase and Adenosine Monophosphate-Activated Protein Kinase in Patients With Hypercholesterolemia
Christie M. Ballantyne et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)
Regulation of Protein Degradation by O-GlcNAcylation: Crosstalk with Ubiquitination
Hai-Bin Ruan et al.
MOLECULAR & CELLULAR PROTEOMICS (2013)
Tet Proteins Connect the O-Linked N-acetylglucosamine Transferase Ogt to Chromatin in Embryonic Stem Cells
Pietro Vella et al.
MOLECULAR CELL (2013)
Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth
Ruiting Lin et al.
MOLECULAR CELL (2013)
Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization
Lei Lv et al.
MOLECULAR CELL (2013)
Histone Acetylation Regulates Intracellular pH
Matthew A. McBrian et al.
MOLECULAR CELL (2013)
SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways
Jeongsoon Park et al.
MOLECULAR CELL (2013)
Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l
L. Chen et al.
LEUKEMIA (2013)
TET2 promotes histone O-GlcNAcylation during gene transcription
Qiang Chen et al.
NATURE (2013)
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
Oliver D. K. Maddocks et al.
NATURE (2013)
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
Joanna Kaplon et al.
NATURE (2013)
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
G. M. Tannahill et al.
NATURE (2013)
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer
Sakari Vanharanta et al.
NATURE MEDICINE (2013)
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
William A. Pastor et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
DNA methylation dynamics in health and disease
Yehudit Bergman et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Multiple Marker Detection in Peripheral Blood for NSCLC Diagnosis
Paola Ulivi et al.
PLOS ONE (2013)
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
Alessandro Michelucci et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation
Ng Shyh-Chang et al.
SCIENCE (2013)
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
Tadahiro Shimazu et al.
SCIENCE (2013)
Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
Basil P. Hubbard et al.
SCIENCE (2013)
(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
Julie-Aurore Losman et al.
SCIENCE (2013)
Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
Peter W. Lewis et al.
SCIENCE (2013)
An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
Dan Rohle et al.
SCIENCE (2013)
Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation
Fang Wang et al.
SCIENCE (2013)
Epigenetic regulation of macrophage polarization and function
Lionel B. Ivashkiv
TRENDS IN IMMUNOLOGY (2013)
Oncogenic Isocitrate Dehydrogenase Mutations: Mechanisms, Models, and Clinical Opportunities
Rob A. Cairns et al.
CANCER DISCOVERY (2013)
Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation
Brian T. Weinert et al.
CELL REPORTS (2013)
Pharmacokinetic and pharmacodynamic analysis of 5-aza-2′-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy
Metin Karahoca et al.
CLINICAL EPIGENETICS (2013)
A proposed role for neutrophil extracellular traps in cancer immunoediting
Sivan Berger-Achituv et al.
FRONTIERS IN IMMUNOLOGY (2013)
Serine, glycine and one-carbon units: cancer metabolism in full circle
Jason W. Locasale
NATURE REVIEWS CANCER (2013)
Folate and DNA Methylation
Anna Ly et al.
ANTIOXIDANTS & REDOX SIGNALING (2012)
ATP-citrate lyase: A mini-review
Melanie Chypre et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
ATP-Citrate Lyase: A Key Player in Cancer Metabolism
Nousheen Zaidi et al.
CANCER RESEARCH (2012)
Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?
Ralph J. DeBerardinis et al.
CELL (2012)
O-GlcNAc Transferase/Host Cell Factor C1 Complex Regulates Gluconeogenesis by Modulating PGC-1α Stability
Hai-Bin Ruan et al.
CELL METABOLISM (2012)
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
Mengtao Xiao et al.
GENES & DEVELOPMENT (2012)
Anticancer Peptidylarginine Deiminase (PAD) Inhibitors Regulate the Autophagy Flux and the Mammalian Target of Rapamycin Complex 1 Activity
Yuji Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Lysine Succinylation and Lysine Malonylation in Histones
Zhongyu Xie et al.
MOLECULAR & CELLULAR PROTEOMICS (2012)
The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation
Dallas R. Donohoe et al.
MOLECULAR CELL (2012)
Reductive carboxylation supports growth in tumour cells with defective mitochondria
Andrew R. Mullen et al.
NATURE (2012)
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Christian M. Metallo et al.
NATURE (2012)
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Chao Lu et al.
NATURE (2012)
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
Peppi Koivunen et al.
NATURE (2012)
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
Michael T. McCabe et al.
NATURE (2012)
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
Sarah K. Knutson et al.
NATURE CHEMICAL BIOLOGY (2012)
Histone methylation: a dynamic mark in health, disease and inheritance
Eric L. Greer et al.
NATURE REVIEWS GENETICS (2012)
Non-targeted metabolite profiling in activated macrophage secretion
Masahiro Sugimoto et al.
METABOLOMICS (2012)
Metabolism of [U-13C]glucose in human brain tumors in vivo
Elizabeth A. Maher et al.
NMR IN BIOMEDICINE (2012)
Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
Tom Latham et al.
NUCLEIC ACIDS RESEARCH (2012)
Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors
Hozefa S. Bandukwala et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription
David F. Allison et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Identification and Functional Expression of the Mitochondrial Pyruvate Carrier
Sebastien Herzig et al.
SCIENCE (2012)
Alterations of metabolic genes and metabolites in cancer
Eric K. Oermann et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)
Regulation of histone modification and chromatin structure by the p53-PADI4 pathway
Chizu Tanikawa et al.
NATURE COMMUNICATIONS (2012)
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
Wenyu Yu et al.
NATURE COMMUNICATIONS (2012)
Folate and DNA Methylation: A Review of Molecular Mechanisms and the Evidence for Folate's Role
Krista S. Crider et al.
ADVANCES IN NUTRITION (2012)
Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP Cells
Limin Shu et al.
AAPS JOURNAL (2011)
R132H-mutation of isocitrate dehydrogenase-1 is not sufficient for HIF-1α upregulation in adult glioma
Susan C. Williams et al.
ACTA NEUROPATHOLOGICA (2011)
Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease
Gerald W. Hart et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80 (2011)
Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications
Brahma N. Singh et al.
BIOCHEMICAL PHARMACOLOGY (2011)
Histone Demethylase LSD1 Is a Folate-Binding Protein
Zigmund Luka et al.
BIOCHEMISTRY (2011)
O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy
Wenyi Mi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)
Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
Scott R. Daigle et al.
CANCER CELL (2011)
Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker
Masashi Takawa et al.
CANCER SCIENCE (2011)
Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival
Caroline H. Yi et al.
CELL (2011)
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Jake E. Delmore et al.
CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Regulation of chromatin by histone modifications
Andrew J. Bannister et al.
CELL RESEARCH (2011)
DNA hypermethylation as a chemotherapy target
Juan Ren et al.
CELLULAR SIGNALLING (2011)
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
Rasheduzzaman Chowdhury et al.
EMBO REPORTS (2011)
Transcriptional and epigenetic regulation of the p53 tumor suppressor gene
Ricardo Saldana-Meyer et al.
EPIGENETICS (2011)
Histone arginine methylation
Alessandra Di Lorenzo et al.
FEBS LETTERS (2011)
AMP-activated protein kinase-an energy sensor that regulates all aspects of cell function
D. Grahame Hardie
GENES & DEVELOPMENT (2011)
Investigating the Pathogenic Role of PADI4 in Oesophageal Cancer
Xiaotian Chang et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2011)
Structure and Biochemical Functions of SIRT6
Patricia W. Pan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Homology modeling, docking and structure-based pharmacophore of inhibitors of DNA methyltransferase
Jakyung Yoo et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2011)
1H NMR-based Metabolomic Profiling in Mice Infected with Mycobacterium tuberculosis
Ji-Hyun Shin et al.
JOURNAL OF PROTEOME RESEARCH (2011)
Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation
Cheryl L. Strelko et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism
Taro Hitosugi et al.
MOLECULAR CELL (2011)
Methionine Adenosyltransferase II Serves as a Transcriptional Corepressor of Maf Oncoprotein
Yasutake Katoh et al.
MOLECULAR CELL (2011)
Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes
Ling Cai et al.
MOLECULAR CELL (2011)
Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase
Wenqing Jiang et al.
MOLECULAR CELL (2011)
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Johannes Zuber et al.
NATURE (2011)
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
Mark A. Dawson et al.
NATURE (2011)
Identification of lysine succinylation as a new post-translational modification
Zhihong Zhang et al.
NATURE CHEMICAL BIOLOGY (2011)
Targeting MYC dependence in cancer by inhibiting BET bromodomains
Jennifer A. Mertz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
David R. Wise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
Jintang Du et al.
SCIENCE (2011)
The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials
Igho Onakpoya et al.
JOURNAL OF OBESITY (2011)
O-GlcNAc signalling: implications for cancer cell biology
Chad Slawson et al.
NATURE REVIEWS CANCER (2011)
AMPK and SIRT1: a long-standing partnership?
Neil B. Ruderman et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)
Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma
Nina Wagener et al.
BMC CANCER (2010)
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
Patrick S. Ward et al.
CANCER CELL (2010)
Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
Maria E. Figueroa et al.
CANCER CELL (2010)
Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development
Tina Bianco-Miotto et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2010)
GlcNAcylation Plays an Essential Role in Breast Cancer Metastasis
Yuchao Gu et al.
CANCER RESEARCH (2010)
Epigenetics, the epicenter of the hypoxic response
Jenny A. Watson et al.
EPIGENETICS (2010)
Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase is regulated by acetylation
Mireia Ventura et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)
Prognostic relevance of global histone H3 lysine 4 (H3K4) methylation in renal cell carcinoma
Joerg Ellinger et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
Specific Contribution of Methionine and Choline in Nutritional Nonalcoholic Steatohepatitis IMPACT ON MITOCHONDRIAL S-ADENOSYL-L-METHIONINE AND GLUTATHIONE
Francisco Caballero et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Myc-dependent Mitochondrial Generation of Acetyl-CoA Contributes to Fatty Acid Biosynthesis and Histone Acetylation during Cell Cycle Entry
Fionnuala Morrish et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Cellular Histone Modification Patterns Predict Prognosis and Treatment Response in Resectable Pancreatic Adenocarcinoma: Results From RTOG 9704
Ananya Manuyakorn et al.
JOURNAL OF CLINICAL ONCOLOGY (2010)
Nuclear-Cytoplasmic Localization of Acetyl Coenzyme A Synthetase-1 in the Rat Brain
Prasanth S. Ariyannur et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2010)
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
Stefan Gross et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
Pingxin Li et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Contribution of Myelin Autoantigen Citrullination to T Cell Autoaggression in the Central Nervous System
Antonio Carrillo-Vico et al.
JOURNAL OF IMMUNOLOGY (2010)
S110, a 5-Aza-2′-Deoxycytidine-Containing Dinucleotide, Is an Effective DNA Methylation Inhibitor In vivo and Can Reduce Tumor Growth
Jody C. Chuang et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
Ji-Hong Lim et al.
MOLECULAR CELL (2010)
SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma
Jean-Pierre Bayley et al.
LANCET ONCOLOGY (2010)
Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia
Y. Shi et al.
LEUKEMIA (2010)
Suppression of inflammation by a synthetic histone mimic
Edwige Nicodeme et al.
NATURE (2010)
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Matthew D. Hirschey et al.
NATURE (2010)
Selective inhibition of BET bromodomains
Panagis Filippakopoulos et al.
NATURE (2010)
β-N-acetylglucosamine (O-GlcNAc) is part of the histone code
Kaoru Sakabe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation
David Bungard et al.
SCIENCE (2010)
Regulation of Cellular Metabolism by Protein Lysine Acetylation
Shimin Zhao et al.
SCIENCE (2010)
Metabolic Modulation of Glioblastoma with Dichloroacetate
E. D. Michelakis et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Global Levels of Histone Modifications Predict Prognosis in Different Cancers
David B. Seligson et al.
AMERICAN JOURNAL OF PATHOLOGY (2009)
Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases
Gema Perez-Chacon et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2009)
Curcumin is a potent DNA hypomethylation agent
Zhongfa Liu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Increased PADI4 expression in blood and tissues of patients with malignant tumors
Xiaotian Chang et al.
BMC CANCER (2009)
SDH5 Mutations and Familial Paraganglioma: Somewhere Warburg is Smiling
William G. Kaelin
CANCER CELL (2009)
A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation
Jharna Datta et al.
CANCER RESEARCH (2009)
Global Histone Modifications in Breast Cancer Correlate with Tumor Phenotypes, Prognostic Factors, and Patient Outcome
Somaia E. Elsheikh et al.
CANCER RESEARCH (2009)
Structure-function relationships in methionine adenosyltransferases
G. D. Markham et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2009)
Structural insight into function and regulation of carnitine palmitoyltransferase
Arne C. Rufer et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2009)
Molecular Modeling and Molecular Dynamics Studies of Hydralazine with Human DNA Methyltransferase 1
Narender Singh et al.
CHEMMEDCHEM (2009)
VHL inactivation is an important pathway for the development of malignant sporadic pancreatic endocrine tumors
A. M. Schmitt et al.
ENDOCRINE-RELATED CANCER (2009)
Conformational signals in the C-terminal domain of methionine adenosyltransferase I/III determine its nucleocytoplasmic distribution
Edel Reytor et al.
FASEB JOURNAL (2009)
Tumor suppressors and cell metabolism: a recipe for cancer growth
Russell G. Jones et al.
GENES & DEVELOPMENT (2009)
Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility
Yi-Jen Liao et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
p53 Chromatin Epigenetic Domain Organization and p53 Transcription
Chia-Hsin Su et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
Andrew Xiao et al.
NATURE (2009)
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
Peter J. Cook et al.
NATURE (2009)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang et al.
NATURE (2009)
JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin
Mark A. Dawson et al.
NATURE (2009)
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Erika L. Pearce et al.
NATURE (2009)
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
Ping Gao et al.
NATURE (2009)
Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis
Rakesh Kumar Singh et al.
NATURE CELL BIOLOGY (2009)
Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
Elaine R. Mardis et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
IDH1 and IDH2 Mutations in Gliomas
Hai Yan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma
Huai-Xiang Hao et al.
SCIENCE (2009)
Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism
Jian Wang et al.
SCIENCE (2009)
Essential Role of the Glycosyltransferase Sxc/Ogt in Polycomb Repression
Maria Cristina Gambetta et al.
SCIENCE (2009)
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
Chunaram Choudhary et al.
SCIENCE (2009)
Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α
Shimin Zhao et al.
SCIENCE (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
Kathryn E. Wellen et al.
SCIENCE (2009)
Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling Reveals System-Wide Modulation of Protein-Protein Interactions
Viveka Mayya et al.
SCIENCE SIGNALING (2009)
Cancer prevention by tea: animal studies, molecular mechanisms and human relevance
Chung S. Yang et al.
NATURE REVIEWS CANCER (2009)
Regulation of Akt signaling by O-GlcNAc in euglycemia
Yudi A. Soesanto et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2008)
p53 induces distinct epigenetic states at its direct target promoters
Lukas Vrba et al.
BMC GENOMICS (2008)
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
Ralph J. DeBerardinis et al.
CELL METABOLISM (2008)
Brick by brick: metabolism and tumor cell growth
Ralph J. DeBerardinis et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2008)
Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis
Hongjie Yao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
O-GlcNAc regulates FoxO activation in response to glucose
Michael P. Housley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Regulation of p53 target gene expression by peptidylarginine deiminase 4
Pingxin Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Sirtuins - novel therapeutic targets to treat age-associated diseases
Siva Lavu et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Flavonoids from carnation (Dianthus caryophyllus) and their antifungal activity
Francesco Galeotti et al.
PHYTOCHEMISTRY LETTERS (2008)
Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer
Sooryanarayana Varambally et al.
SCIENCE (2008)
Hepatic glucose sensing via the CREB coactivator CRTC2
Renaud Dentin et al.
SCIENCE (2008)
An integrated genomic analysis of human glioblastoma Multiforme
D. Williams Parsons et al.
SCIENCE (2008)
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
M. Luz Martinez-Chantar et al.
HEPATOLOGY (2008)
Review article: the role of butyrate on colonic function
H. M. Hamer et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2008)
Structure and mechanism of lysine-specific demethylase enzymes
Ruchi Anand et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Inhibition of DNA methylation by antisense oligonucleotide MG98 as cancer therapy
Robert J. Amato
CLINICAL GENITOURINARY CANCER (2007)
A polycomb repression signature in metastatic prostate cancer predicts cancer outcome
Jindan Yu et al.
CANCER RESEARCH (2007)
Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation
Alexander Golks et al.
EMBO JOURNAL (2007)
L-2-Hydroxyglutaric aciduria, a defect of metabolite repair
R. Rzem et al.
JOURNAL OF INHERITED METABOLIC DISEASE (2007)
Global histone modifications predict prognosis of resected non-small-cell lung cancer
Fabrice Barlesi et al.
JOURNAL OF CLINICAL ONCOLOGY (2007)
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
Hongying Yang et al.
CELL (2007)
PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation
Alessio Zippo et al.
NATURE CELL BIOLOGY (2007)
Delivery of 5-aza-2′-deoxycytidine to cells using oligodeoxynucleotides
Christine B. Yoo et al.
CANCER RESEARCH (2007)
2-Hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors
James J. Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Connections between epigenetic gene silencing and human disease
Timothy J. Moss et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2007)
Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins
Gerald W. Hart et al.
NATURE (2007)
The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis
Mario A. Moscarello et al.
NEUROCHEMICAL RESEARCH (2007)
FDA approval summary: Vorinostat for treatment of advanced primary cutaneous T-cell lymphoma
Bhupinder S. Mann et al.
ONCOLOGIST (2007)
Nucleocytosolic acetyl-coenzyme A synthetase is required for histone acetylation and global transcription
Hidekazu Takahashi et al.
MOLECULAR CELL (2006)
Homeodomain-mediated β-catenin-dependent switching events dictate cell-lineage determination
Lorin E. Olson et al.
CELL (2006)
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
I Papandreou et al.
CELL METABOLISM (2006)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
PTEN promoter methylation in sporadic thyroid carcinomas
F Alvarez-Nunez et al.
THYROID (2006)
Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription
F Faiola et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
ATP citrate lyase inhibition can suppress tumor cell growth
G Hatzivassiliou et al.
CANCER CELL (2005)
Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2′-deoxycytidine
JC Chuang et al.
MOLECULAR CANCER THERAPEUTICS (2005)
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
MK Jang et al.
MOLECULAR CELL (2005)
Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
B Brueckner et al.
CANCER RESEARCH (2005)
Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation
HS Choi et al.
CANCER RESEARCH (2005)
Global histone modification patterns predict risk of prostate cancer recurrence
DB Seligson et al.
NATURE (2005)
Overview of the molecular and biochemical basis of branched-chain amino acid catabolism
RA Harris et al.
JOURNAL OF NUTRITION (2005)
Plasma pharmacokinetics, oral bioavailability, and interspecies scaling of the DNA methyltransferase inhibitor, zebularine
JL Holleran et al.
CLINICAL CANCER RESEARCH (2005)
Approval summary: Azacitidine for treatment of myelodysplastic syndrome subtypes
E Kaminskas et al.
CLINICAL CANCER RESEARCH (2005)
Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma
M Pufulete et al.
GUT (2005)
Bioavailability of azacitidine subcutaneous versus intravenous in patients with the myelodysplastic syndromes
G Marcucci et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2005)
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
MF Fraga et al.
NATURE GENETICS (2005)
FDA drug approval summary:: Azacitidine (5-azacytidine, Vidaza™) for injectable suspension
E Kaminskas et al.
ONCOLOGIST (2005)
Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation
SJ Nowak et al.
TRENDS IN GENETICS (2004)
Promoter methylation of the PTEN gene is a common molecular change in breast cancer
JM García et al.
GENES CHROMOSOMES & CANCER (2004)
The butyrate story: old wine in new bottles?
W Scheppach et al.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2004)
Division of labor in Polycomb group repression
SS Levine et al.
TRENDS IN BIOCHEMICAL SCIENCES (2004)
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
JG Wood et al.
NATURE (2004)
Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1
YJ Shi et al.
CELL (2004)
Human PAD4 regulates histone arginine methylation levels via demethylimination
Y Wang et al.
SCIENCE (2004)
TAF1 activates transcription by phosphorylation of serine 33 in histone H2B
T Maile et al.
SCIENCE (2004)
Immune-responsive gene 1 is a novel target of progesterone receptor and plays a critical role during implantation in the mouse
YP Cheon et al.
ENDOCRINOLOGY (2003)
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
KT Howitz et al.
NATURE (2003)
Establishment and functional validation of a structural homology model for human DNA methyltransferase 1
P Siedlecki et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression
V Anest et al.
NATURE (2003)
MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14
A Soloaga et al.
EMBO JOURNAL (2003)
Chromosomal instability and tumors promoted by DNA hypomethylation
A Eden et al.
SCIENCE (2003)
Induction of tumors in mice by genomic hypomethylation
F Gaudet et al.
SCIENCE (2003)
Histone deacetylases (HDACs): characterization of the classical HDAC family
AJM De Ruijter et al.
BIOCHEMICAL JOURNAL (2003)
Role of histone H3 lysine 27 methylation in polycomb-group silencing
R Cao et al.
SCIENCE (2002)
The polycomb group protein EZH2 is involved in progression of prostate cancer
S Varambally et al.
NATURE (2002)
Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase
N Lacoste et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation:: mechanistic studies and their implications for cancer therapy
JK Christman
ONCOGENE (2002)
Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation
C Alarcon et al.
DIABETES (2002)
Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A:: Coupling protein O-GlcNAcylation to transcriptional repression
XY Yang et al.
CELL (2002)
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain
Q Feng et al.
CURRENT BIOLOGY (2002)
The fundamental role of epigenetic events in cancer
PA Jones et al.
NATURE REVIEWS GENETICS (2002)
DNA methyltransferase inhibitors - state of the art
J Goffin et al.
ANNALS OF ONCOLOGY (2002)
Promoter methylation and silencing of PTEN in gastric carcinoma
YH Kang et al.
LABORATORY INVESTIGATION (2002)
Increased N-acetyl-β-glucosaminidase activity in primary breast carcinomas corresponds to a decrease in N-acetylglucosamine containing proteins
C Slawson et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2001)
Snf1 - a histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription
WS Lo et al.
SCIENCE (2001)
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma
D Astuti et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation
RR Adams et al.
JOURNAL OF CELL BIOLOGY (2001)
Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate
T Fujino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Drosophila Aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis
R Giet et al.
JOURNAL OF CELL BIOLOGY (2001)
Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins
A Luong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
5′-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer
J Trojan et al.
GUT (2000)
Deimination of myelin basic protein. 1. Effect of deimination of arginyl residues of myelin basic protein on its structure and susceptibility to digestion by cathepsin D
LB Pritzker et al.
BIOCHEMISTRY (2000)
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
BE Baysal et al.
SCIENCE (2000)
Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome
M Esteller et al.
ONCOGENE (2000)
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