4.7 Review

Metabolic reprogramming and epigenetic modifications on the path to cancer

期刊

PROTEIN & CELL
卷 13, 期 12, 页码 877-919

出版社

OXFORD UNIV PRESS
DOI: 10.1007/s13238-021-00846-7

关键词

metabolic reprogramming; epigenetics; tumorigenesis; tumor immunity; cancer therapy

资金

  1. National Natural Science Foundation of China [91957203, 81930083, 81874060, 81821001]
  2. National Key R&D Program of China [2018YFA0107103, 2018YFA0800300, 2017YFA0205600]
  3. Chinese Academy of Sciences [XDB39000000]
  4. Program for Guangdong Introducing Innovative and Entrepreneurial Teams [2017ZT07S054]
  5. Outstanding Scholar Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory [2018GZR110102001]
  6. Fundamental Research Funds for the Central Universities [YD2070002008, 2020ZYGXZR038]

向作者/读者索取更多资源

Metabolic rewiring and epigenetic remodeling, which are closely linked in cancer development, play important roles in tumor progression and immune escape. Metabolites can affect the function of chromatin-modifying enzymes, influencing processes such as tumor progression and immunosurveillance.
Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally regulate each other, are among the well-known cancer hallmarks. Recent evidence suggests that many metabolites serve as substrates or cofactors of chromatin-modifying enzymes as a consequence of the translocation or spatial regionalization of enzymes or metabolites. Various metabolic alterations and epigenetic modifications also reportedly drive immune escape or impede immunosurveillance within certain contexts, playing important roles in tumor progression. In this review, we focus on how metabolic reprogramming of tumor cells and immune cells reshapes epigenetic alterations, in particular the acetylation and methylation of histone proteins and DNA. We also discuss other eminent metabolic modifications such as, succinylation, hydroxybutyrylation, and lactylation, and update the current advances in metabolism- and epigenetic modification-based therapeutic prospects in cancer.

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