4.7 Review

Review of Applications and Future Prospects of Stimuli-Responsive Hydrogel Based on Thermo-Responsive Biopolymers in Drug Delivery Systems

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Multidisciplinary

Polymers Exhibiting Lower Critical Solution Temperatures as a Route to Thermoreversible Gelators for Healthcare

Michael T. Cook et al.

Summary: Materials with smart behavior that can change their properties in response to external stimuli have enabled innovative technologies for healthcare applications. Thermoreversible gelators, which undergo reversible phase changes triggered by temperature, are being used for drug delivery, tissue engineering, and 3D printing. Challenges in translating these technologies include the lack of rigorous toxicological evaluation.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Biochemistry & Molecular Biology

Bioinspired Thermoresponsive Xyloglucan-Cellulose Nanocrystal Hydrogels

Malika Talantikite et al.

Summary: This study reported the preparation and application of thermoresponsive hydrogels composed of xyloglucan and cellulose nanocrystals, showing that the properties of the gels could be adjusted by specific mixing ratios and exhibiting a reversible thermal transition behavior. This thermoresponsive behavior provides opportunities for wide applications, especially in the biomedical field, where the mechanical properties could be further tuned by adjusting the content of cellulose nanocrystals.

BIOMACROMOLECULES (2021)

Article Biochemistry & Molecular Biology

Influence of pH-responsive compounds synthesized from chitosan and hyaluronic acid on dual-responsive (pH/temperature) hydrogel drug delivery systems of Cortex Moutan

Sudipta Chatterjee et al.

Summary: The study utilized polysaccharide-based pH-responsive compounds to enhance the pH stability and mechanical properties of PF127-based drug delivery systems, resulting in improved drug release behavior. Morphological analysis also showed better structures in the systems.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Cell & Tissue Engineering

Thermo-Responsive Methylcellulose Hydrogels: From Design to Applications as Smart Biomaterials

Lorenzo Bonetti et al.

Summary: Methylcellulose (MC) hydrogels exhibit thermo-responsive behavior, changing properties in response to temperature changes, making them suitable for cell and drug delivery, tissue engineering, and regenerative medicine applications. They undergo sol-gel transition at a critical temperature, allowing for tissue regeneration in various contexts.

TISSUE ENGINEERING PART B-REVIEWS (2021)

Review Biochemistry & Molecular Biology

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Luis Castillo-Henriquez et al.

Summary: Innate and adaptive immune responses play a role in wound healing by promoting cellular cross-talk, with the help of smart thermo-responsive polymers providing physical support for tissue regeneration and acting as drug delivery systems. These biomaterials can regulate drug release by locally heating tumors and converting into a hydrophobic form, aiding in tissue healing and preventing bacterial infections. The review highlights the potential of bioengineered scaffolds composed of smart thermo-responsive polymers to provide spatially and temporally controlled drug release strategies for wound healing.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Chemistry, Physical

Textile Materials Modified with Stimuli-Responsive Drug Carrier for Skin Topical and Transdermal Delivery

Daniela Atanasova et al.

Summary: Textile materials are suitable matrices for active substances in skin therapy, providing various loading methods for specific treatment needs. Research focuses on developing intelligent materials for controlled delivery of active substances.

MATERIALS (2021)

Article Biochemistry & Molecular Biology

Alginate-g-PNIPAM-Based Thermo/Shear-Responsive Injectable Hydrogels: Tailoring the Rheological Properties by Adjusting the LCST of the Grafting Chains

Konstantinos Safakas et al.

Summary: The study focused on the thermoresponsive hydrogels formed by graft copolymers of alginate backbone and N-isopropylacrylamide/N-tert-butylacrylamide random copolymer, with the rheological properties being greatly influenced by the NtBAM hydrophobic content. Enriching the PNIPAM chains with 20 mol % NtBAM led to a significant shift in the gelation point to lower temperatures, impacting the hydrogels' behavior at different temperatures.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Pharmacology & Pharmacy

Thermosensitive nasal in situ gelling systems of rufinamide formulated using modified tamarind seed xyloglucan for direct nose-to-brain delivery: design, physical characterization, and in vivo evaluation

Avantika V. Dalvi et al.

Summary: The study demonstrated that formulating a nasal gel can enhance the brain bioavailability of rufinamide compared to oral administration. The optimized formulation showed good gelation properties in in vivo rat studies, improving direct nose to brain uptake of the drug.

JOURNAL OF PHARMACEUTICAL INVESTIGATION (2021)

Article Biochemistry & Molecular Biology

Rheological Investigation of Thermoresponsive Alginate-Methylcellulose Gels for Epidermal Growth Factor Formulation

Olivia Eskens et al.

Summary: An alginate-methylcellulose gel system offers superior viscosity and thermoresponsiveness compared to individual components, with increased methylcellulose concentration enhancing gel elasticity and providing better thermal protection of EGF. EGF concentration plays a significant role in the shear viscosity and thermoresponsiveness of the ternary system. This system shows promising rheological tunability for providing EGF thermal protection in topical delivery.

COSMETICS (2021)

Article Cell & Tissue Engineering

Design Considerations for Hydrogel Wound Dressings: Strategic and Molecular Advances

Roel C. Op't Veld et al.

TISSUE ENGINEERING PART B-REVIEWS (2020)

Article Medicine, Research & Experimental

Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in vivo and in vitro study

Kwang Ho Yoo et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

Review Materials Science, Multidisciplinary

Hybrid Thermo-Responsive Polymer Systems and Their Biomedical Applications

Taskeen Sarwan et al.

FRONTIERS IN MATERIALS (2020)

Article Biochemical Research Methods

Aggregation behaviors of thermo-responsive methylcellulose in water: A molecular dynamics simulation study

Yang Yang et al.

JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2020)

Review Chemistry, Applied

Thermoresponsive polysaccharides and their thermoreversible physical hydrogel networks

Sarah Graham et al.

CARBOHYDRATE POLYMERS (2019)

Article Pharmacology & Pharmacy

Smart thermosensitive chitosan hydrogel for nasal delivery of ibuprofen to treat neurological disorders

Hanieh Gholizadeh et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

Article Biochemistry & Molecular Biology

Dual thermo-and pH-sensitive injectable hydrogels of chitosan/(poly(N-isopropylacrylamide-co-itaconic acid)) for doxorubicin delivery in breast cancer

Marziyeh Fathi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Review Biochemistry & Molecular Biology

Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application

Sudipta Chatterjee et al.

MOLECULES (2019)

Review Chemistry, Physical

Elastin-like polypeptides as building motifs toward designing functional nanobiomaterials

Duc H. T. Le et al.

MOLECULAR SYSTEMS DESIGN & ENGINEERING (2019)

Review Engineering, Biomedical

Biopolymer-based strategies in the design of smart medical devices and artificial organs

Lina Altomare et al.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2018)

Article Engineering, Biomedical

Functionalization of Cotton Fabrics with Polycaprolactone Nanoparticles for Transdermal Release of Melatonin

Daniele Massella et al.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2018)

Article Chemistry, Multidisciplinary

Gelatin-Based Hydrogels Blended with Gellan as an Injectable Wound Dressing

Yueyuan Zheng et al.

ACS OMEGA (2018)

Review Engineering, Biomedical

Cellulose-based hydrogel materials: chemistry, properties and their prospective applications

S. M. Fijul Kabir et al.

PROGRESS IN BIOMATERIALS (2018)

Article Engineering, Biomedical

Bioprinted chitosan-gelatin thermosensitive hydrogels using an inexpensive 3D printer

Kevin D. Roehm et al.

BIOFABRICATION (2018)

Article Instruments & Instrumentation

A methylcellulose and collagen based temperature responsive hydrogel promotes encapsulated stem cell viability and proliferation in vitro

Christina Payne et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2017)

Article Nanoscience & Nanotechnology

Redox-sensitive Pluronic F127-tocopherol micelles: synthesis, characterization, and cytotoxicity evaluation

Yuling Liu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

Article Materials Science, Multidisciplinary

Thermo-responsive properties of methylcellulose hydrogels for cell sheet engineering

Nicola Contessi et al.

MATERIALS LETTERS (2017)

Review Polymer Science

How to manipulate the upper critical solution temperature (UCST)?

Jukka Niskanen et al.

POLYMER CHEMISTRY (2017)

Article Nanoscience & Nanotechnology

Self-Activated Healable Hydrogels with Reversible Temperature Responsiveness

Ruixue Chang et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Review Materials Science, Biomaterials

Classification, processing and application of hydrogels: A review

Faheem Ullah et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2015)

Article Pharmacology & Pharmacy

Assessment of release kinetics, stability and polymer interaction of poloxamer 407-based thermosensitive gel of interleukin-1 receptor antagonist

Muhammad Sajid Hamid Akash et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2014)

Article Instruments & Instrumentation

Smart hydrogel-functionalized textile system with moisture management property for skin application

Xiaowen Wang et al.

SMART MATERIALS AND STRUCTURES (2014)

Review Materials Science, Biomaterials

Multi-responsive hydrogels for drug delivery and tissue engineering applications

Jennifer M. Knipe et al.

REGENERATIVE BIOMATERIALS (2014)

Article Materials Science, Multidisciplinary

Properties and drug release profile of poly(N-isopropylacrylamide) microgels functionalized with maleic anhydride and alginate

Stojanka Petrusic et al.

JOURNAL OF MATERIALS SCIENCE (2013)

Article Materials Science, Biomaterials

Bioactive cotton fabrics containing chitosan and biologically active substances extracted from plants

G. Mocanu et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2013)

Article Pharmacology & Pharmacy

Thermally reversible xyloglucan gels as vehicles for nasal drug delivery

Hitendra S. Mahajan et al.

DRUG DELIVERY (2012)

Article Pharmacology & Pharmacy

Effect of salts on gelation and drug release profiles of methylcellulose-based ophthalmic thermo-reversible in situ gels

Manas Bhowmik et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2011)

Article Chemistry, Applied

Study on the sol-gel transition of xyloglucan hydrogels

Amanda K. Andriola Silva Brun-Graeppi et al.

CARBOHYDRATE POLYMERS (2010)

Review Pharmacology & Pharmacy

Thermoresponsive hydrogels in biomedical applications

Leda Klouda et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2008)

Review Polymer Science

Hydrogels in drug delivery: Progress and challenges

Todd R. Hoare et al.

POLYMER (2008)

Article Pharmacology & Pharmacy

Potential application of Metolose® in a thermoresponsive transdermal therapeutic system

G. Csoka et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2007)

Article Engineering, Biomedical

Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering

K. E. Crompton et al.

BIOMATERIALS (2007)

Article Polymer Science

On the nature of crosslinks in thermoreversible gels

Klaas te Nijenhuis

POLYMER BULLETIN (2007)

Article Pharmacology & Pharmacy

Drug-polymer interactions and their effect on thermoresponsive poly(N-isopropylacrylamide) drug delivery systems

DC Coughlan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2006)

Review Pharmacology & Pharmacy

Hydrogels for biomedical applications

AS Hoffman

ADVANCED DRUG DELIVERY REVIEWS (2002)

Article Pharmacology & Pharmacy

In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride

S Miyazaki et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2001)