期刊
POLYMERS
卷 13, 期 13, 页码 -出版社
MDPI
DOI: 10.3390/polym13132086
关键词
thermo-responsive hydrogel; biopolymer; drug delivery; LCST; polysaccharide; transdermal therapy
资金
- Block Grant of the Faculty of Applied Science and Textiles, The Hong Kong Polytechnic University [1-ZVLM]
Thermo-responsive polysaccharides and protein-like materials have temperature-dependent sol-gel transitions, making them valuable for drug delivery and tissue engineering applications. Their biocompatibility, biodegradability, and non-toxicity make them ideal for such medical uses.
Some of thermo-responsive polysaccharides, namely, cellulose, xyloglucan, and chitosan, and protein-like gelatin or elastin-like polypeptides can exhibit temperature dependent sol-gel transitions. Due to their biodegradability, biocompatibility, and non-toxicity, such biomaterials are becoming popular for drug delivery and tissue engineering applications. This paper aims to review the properties of sol-gel transition, mechanical strength, drug release (bioavailability of drugs), and cytotoxicity of stimuli-responsive hydrogel made of thermo-responsive biopolymers in drug delivery systems. One of the major applications of such thermos-responsive biopolymers is on textile-based transdermal therapy where the formulation, mechanical, and drug release properties and the cytotoxicity of thermo-responsive hydrogel in drug delivery systems of traditional Chinese medicine have been fully reviewed. Textile-based transdermal therapy, a non-invasive method to treat skin-related disease, can overcome the poor bioavailability of drugs from conventional non-invasive administration. This study also discusses the future prospects of stimuli-responsive hydrogels made of thermo-responsive biopolymers for non-invasive treatment of skin-related disease via textile-based transdermal therapy.
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