期刊
POLYMERS
卷 13, 期 13, 页码 -出版社
MDPI
DOI: 10.3390/polym13132094
关键词
sporopollenin; microcapsules; pollen; sunflower; chamomile; FTIR; SEM
资金
- Xunta de Galicia
- European Union (European Regional Development Fund-ERDF)
- Ministerio de Ciencia e Innovacion, Gobierno de Espana-FEDER [PID2019-107500RB-I00, ERC2018-092841]
The study introduces a simplified method to produce stable and pristine hollow pollen microcapsules, with a complete physicochemical and morphological characterization of the intermediate and final products. The optimized procedure has been validated for different pollen samples, showing potential for pharmaceutical applications as a drug delivery platform.
Pollen grains are natural microcapsules comprised of the biopolymer sporopollenin. The uniformity and special tridimensional architecture of these sporopollenin structures confer them attractive properties such as high resistance and improved bioadhesion. However, natural pollen can be a source of allergens, hindering its biomedical applicability. Several methods have been developed to remove internal components and allergenic compounds, usually involving long and laborious processes, which often cannot be extended to other pollen types. In this work, we propose an abridged protocol to produce stable and pristine hollow pollen microcapsules, together with a complete physicochemical and morphological characterization of the intermediate and final products. The optimized procedure has been validated for different pollen samples, also producing sporopollenin microcapsules from Matricaria species for the first time. Pollen microcapsules obtained through this protocol presented low protein content (4.4%), preserved ornamented morphology with a nanoporous surface, and low product density (0.14 g/cm(3)). These features make them interesting candidates from a pharmaceutical perspective due to the versatility of this biomaterial as a drug delivery platform.
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