期刊
POLYMERS
卷 13, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/polym13121948
关键词
bioelectronics; conducting polymer; doping; neural interface; PEDOT
资金
- National Science Centre, Poland [SONATA 2016/23/D/ST5/01306, OPUS 2019/35/B/ST5/00995]
- Silesian University of Technology, Poland [04/040/BK_21/0145, 04/040/BKM21/0178, 04/040/BKM21/0162, 04/040/RGJ21/0147]
The study focused on electrochemical doping of conducting polymers as a strategy enabling the efficient manufacturing of interfacing platforms, in which features could be easily adjusted. The results demonstrated that PEDOT-based materials can be efficiently tuned with diversified physicochemical properties by choosing the dopant and doping conditions. Thus, electrochemical doping of PEDOT was proven as a valuable strategy facilitating the development of promising tissue interfacing materials with tailored characteristics.
The aspiration to interact living cells with electronics challenges researchers to develop materials working at the interface of these two distinct environments. A successful interfacing coating should exhibit both biocompatibility and desired functionality of a bio-integrated device. Taking into account biodiversity, the tissue interface should be fine-tuned to the specific requirements of the bioelectronic systems. In this study, we pointed to electrochemical doping of conducting polymers as a strategy enabling the efficient manufacturing of interfacing platforms, in which features could be easily adjusted. Consequently, we fabricated conducting films based on a poly(3,4-ethylenedioxythiophene) (PEDOT) matrix, with properties modulated through doping with selected ions: PSS- (poly(styrene sulfonate)), ClO4- (perchlorate), and PF6- (hexafluorophosphate). Striving to extend the knowledge on the relationships governing the dopant effect on PEDOT films, the samples were characterized in terms of their chemical, morphological, and electrochemical properties. To investigate the impact of the materials on attachment and growth of cells, rat neuroblastoma B35 cells were cultured on their surface and analyzed using scanning electron microscopy and biological assays. Eventually, it was shown that through the choice of a dopant and doping conditions, PEDOT-based materials can be efficiently tuned with diversified physicochemical properties. Therefore, our results proved electrochemical doping of PEDOT as a valuable strategy facilitating the development of promising tissue interfacing materials with characteristics tailored as required.
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