4.7 Article

Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses

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Summary: The APOBEC3 genes in mammals have evolved and diversified significantly, likely due to conflicts with ancient viruses. Lentiviruses, including HIV, are known to encode a protein called Vif to counteract the antiviral effects of APOBEC3 proteins. The acquisition of anti-APOBEC3 ability by lentiviruses is crucial for successful cross-species transmission.

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