4.6 Article

Neutrophils promote T-cell activation through the regulated release of CD44-bound Galectin-9 from the cell surface during HIV infection

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Summary: The outbreak of SARS-CoV-2 infection has significantly impacted our lives, with cytokine release syndrome being identified as a major cause of mortality in COVID-19 patients. Studies have shown a substantial increase in plasma Galectin-9 (Gal-9) levels in COVID-19 patients compared to healthy controls. Gal-9 may play a critical role in the pathogenesis of COVID-19, and inhibiting Gal-9 could be a potential therapeutic strategy to modulate hyperimmune activation in these patients.
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