4.6 Review

Recent insights into mechanisms preventing ectopic centromere formation

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Summary: A newly formed neocentromere in human cells was reported, which was formed purely epigenetically and showed the assembly of a functional kinetochore correlated with CENP-A seeding, eviction of H3K9me3, and local accumulation of mitotic cohesin and RNA polymerase II. Over time, the neocentromere showed increased CPC assembly and low-level transcription, indicating centromere maturation.

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