期刊
OPEN BIOLOGY
卷 11, 期 8, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsob.210130
关键词
primary cilia; lipid raft dynamics; Akt; adipogenesis; cancer
资金
- Japan Society for the Promotion of Science KAKENHI [19K07318, 20K07356, 20K07371, 18K06890, 19K09708, 21H02696]
- Takeda Science Foundation
- Naito Foundation
- Grants-in-Aid for Scientific Research [18K06890, 19K09708, 21H02696, 20K07356, 20K07371] Funding Source: KAKEN
This review highlights the importance of primary cilia and lipid rafts in signal transduction and cellular function regulation, discussing their relationship in adipogenesis and cancer biology, providing a novel research perspective.
Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular cues and transduce signals into the cell to regulate a wide range of functions. Lipid rafts, plasma membrane microdomains enriched in cholesterol, sphingolipids and specific proteins, are also signalling hubs involved in a myriad of physiological functions. Although impairment of primary cilia and lipid rafts is associated with various diseases, the relationship between primary cilia and lipid rafts is poorly understood. Here, we review a newly discovered interaction between primary cilia and lipid raft dynamics that occurs during Akt signalling in adipogenesis. We also discuss the relationship between primary cilia and lipid raft-mediated Akt signalling in cancer biology. This review provides a novel perspective on primary cilia in the regulation of lipid raft dynamics.
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