期刊
MOLECULAR BRAIN
卷 14, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13041-021-00795-6
关键词
mGluR-LTD; mTOR; Dendritic spines; Proteomics; Down syndrome; Synaptoneurosomes; Trisomy 21
资金
- Junta de Andalucia (Spain) [P12-CTS-1818]
- Ministerio de Economia, Industria y Competitividad (Spain) [SAF2015-65032-R]
- Fondo Europeo de Desarrollo Regional (FEDER)
- Fondation Jerome Lejeune (France)
Down syndrome (DS) is associated with memory deficits due to hippocampal-related issues, with experimental models showing alterations in synaptic plasticity pathways. Enhanced mGluR-LTD and increased mushroom spines in hippocampal neurons in Ts1Cje mice contribute to memory deficits. Prenatal rapamycin treatment shows positive effects on both phenotypes, suggesting therapeutic potential for DS intellectual disability.
Down syndrome (DS) is the most frequent genetic cause of intellectual disability including hippocampal-dependent memory deficits. We have previously reported hippocampal mTOR (mammalian target of rapamycin) hyperactivation, and related plasticity as well as memory deficits in Ts1Cje mice, a DS experimental model. Here we characterize the proteome of hippocampal synaptoneurosomes (SNs) from these mice, and found a predicted alteration of synaptic plasticity pathways, including long term depression (LTD). Accordingly, mGluR-LTD (metabotropic Glutamate Receptor-LTD) is enhanced in the hippocampus of Ts1Cje mice and this is correlated with an increased proportion of a particular category of mushroom spines in hippocampal pyramidal neurons. Remarkably, prenatal treatment of these mice with rapamycin has a positive pharmacological effect on both phenotypes, supporting the therapeutic potential of rapamycin/rapalogs for DS intellectual disability.
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