期刊
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
卷 18, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/ijerph18147239
关键词
first-episode psychosis; early intervention; treatment; outcome; randomised controlled trial
资金
- Spanish Ministry of Economy and Competitiveness through the Carlos III Health Institute (ISCIII)
- European Regional Development Fund (ERDF) [PI10/01430, PI15/00789, PI18/0155, PI19/00569]
The study found that using cognitive behavioral therapy as an adjunctive treatment can improve functioning, reduce depressive, negative, and general psychotic symptoms, and enhance treatment adherence for first-episode psychosis patients. This integrated treatment approach may help improve clinical and functional outcomes for first-episode psychosis.
Introduction: There is evidence that early intervention contributes to improving the prognosis and course of first-episode psychosis (FEP). However, further randomised treatment clinical trials are needed. Objectives: The aim of this study was to compare the efficacy of a combined clinical treatment involving Cognitive Behavioural Therapy (CBT) as an adjunctive to treatment-as-usual (TAU) (CBT+TAU) versus TAU alone for FEP. Patients and methods: In this multicentre, single-blind, randomised controlled trial, 177 participants were randomly allocated to either CBT+TAU or TAU. The primary outcome was post-treatment patient functioning. Results: The CBT+TAU group showed a greater improvement in functioning, which was measured using the Global Assessment Functioning (GAF) and Functioning Assessment Short Test (FAST), compared to the TAU group post-treatment. The CBT+TAU participants exhibited a greater decline in depressive, negative, and general psychotic symptoms; a better awareness of the disease and treatment adherence; and a greater increase in brain-derived neurotrophic factor levels than TAU participants. Conclusions: Early intervention based on a combined clinical treatment involving CBT as an adjunctive to standard treatment may improve clinical and functional outcomes in FEP.
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