4.3 Article

Microbiome of Unilateral Chronic Rhinosinusitis: A Controlled Paired Analysis

出版社

MDPI
DOI: 10.3390/ijerph18189878

关键词

microbiome; 16S rRNA sequencing; rhinosinusitis; unilateral sinusitis

资金

  1. Korea University Guro Hospital (KOREA RESEARCH-DRIVEN HOSPITAL) [O2001091]
  2. Hallym University Research Fund
  3. National Research Foundation of Korea - Ministry of Education [2020R1I1A3067369]
  4. National Research Foundation of Korea [2020R1I1A3067369] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

This study found that the relative abundances of Staphylococcus and Pseudomonas were significantly lower in samples from the diseased site of unilateral chronic rhinosinusitis, while anaerobes were more abundant in the diseased site.
The sinonasal microbiota in human upper airway may play an important role in chronic rhinosinusitis (CRS). Thus, this study aimed to investigate the human upper airway microbiome in patients with unilateral CRS, and compare the sinonasal microbiome of the unilateral diseased site with that of a contralateral healthy site. Thirty samples, 15 each from the diseased and healthy sites, were collected from the middle meatus and/or anterior ethmoid region of 15 patients with unilateral CRS during endoscopic sinus surgery. DNA extraction and bacterial microbiome analysis via 16S rRNA gene sequencing were then performed. Corynebacterium showed the highest relative abundance, followed by Staphylococcus in samples from both the diseased and healthy sites. Further, the relative abundances of Staphylococcus and Pseudomonas were significantly lower in samples from diseased sites than in those from healthy sites. Conversely, anaerobes, including Fusobacterium, Bacteroides, and Propionibacterium, were abundantly present in samples from both sites, more so in samples from diseased sites. However, the sites showed no significant difference with respect to richness or diversity (p > 0.05). Our results indicate that CRS might be a polymicrobial infection, and also suggest that Corynebacterium and Staphylococcus may exist as commensals on the sinus mucosal surface in the upper respiratory tract.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据