4.7 Article

Single-cell exome sequencing reveals multiple subclones in metastatic colorectal carcinoma

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Article Genetics & Heredity

Single-cell exome sequencing reveals multiple subclones in metastatic colorectal carcinoma

Jie Tang et al.

Summary: In this study, despite low genomic divergence between primary and metastatic cancers in bulk data, single-cell whole-exome sequencing data revealed rare mutations and defined two separate cell populations, indicating diverse evolutionary trajectories between primary and metastatic tumor cells. Additionally, 24 metastatic cell-specific mutated genes were identified and their functions in cell migration capacity were validated.

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