4.3 Article

Easy identification of insertion sequence mobilization events in related bacterial strains with ISCompare

期刊

G3-GENES GENOMES GENETICS
卷 11, 期 8, 页码 -

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/g3journal/jkab181

关键词

insertion sequence; transposon; genomics; Group II introns

资金

  1. Ministry of Science Technology and Productive Innovation (Ministerio de Ciencia Tecnologia e Innovacion Productiva-MinCyT, Argentina) [PICT2016-0171]
  2. CONICET
  3. MinCyT

向作者/读者索取更多资源

Bacterial genomes consist of core and accessory genomes, with ISs playing a crucial role in genome evolution and adaptability. ISCompare is a new tool that can analyze differentially located ISs in related bacterial strains, providing a quick and simple approach for researchers.
Bacterial genomes are composed of core and accessory genomes. The first is composed of housekeeping and essential genes, while the second is highly enriched in mobile genetic elements, including transposable elements (TEs). Insertion sequences (ISs), the smallest TEs, have an important role in genome evolution, and contribute to bacterial genome plasticity and adaptability. ISs can spread in a genome, presenting different locations in nearly related strains, and producing phenotypic variations. Few tools are available which can identify differentially located ISs (DLISs) on assembled genomes. Here, we introduce ISCompare, a new program to profile IS mobilization events in related bacterial strains using complete or draft genome assemblies. ISCompare was validated using artificial genomes with simulated random IS insertions and real sequences, achieving the same or better results than other available tools, with the advantage that ISCompare can analyze multiple ISs at the same time and outputs a list of candidate DLISs. ISCompare provides an easy and straightforward approach to look for differentially located ISs on bacterial genomes.

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