Theta-Range Oscillations in Stress-Induced Mental Disorders as an Oscillotherapeutic Target

Emotional behavior and psychological disorders are expressed through coordinated interactions across multiple brain regions. Brain electrophysiological signals are composed of diverse neuronal oscillations, representing cell-level to region-level neuronal activity patterns, and serve as a biomarker of mental disorders. Here, we review recent observations from rodents demonstrating how neuronal oscillations in the hippocampus, amygdala, and prefrontal cortex are engaged in emotional behavior and altered by psychiatric changes such as anxiety and depression. In particular, we focus mainly on theta-range (4-12 Hz) oscillations, including several distinct oscillations in this frequency range. We then discuss therapeutic possibilities related to controlling such mental disease-related neuronal oscillations to ameliorate psychiatric symptoms and disorders in rodents and humans.

Automated summary

Studying rodent models has revealed the intricate relationship between neuronal oscillations in the brain and emotional behavior as well as psychiatric disorders. Specifically focusing on theta-range (4-12 Hz) oscillations offers insights into potential therapeutic interventions for ameliorating psychiatric symptoms and disorders in both rodents and humans.