期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2021.702231
关键词
combination therapy; neuroinflammation; neurotransmitter; postoperative cognitive dysfunction; sevoflurane anesthesia
资金
- Natural Science Foundation of Fujian Province [2020J01227]
- Medical Innovation Science and Technology Project of Fujian Province [2020CXA047]
- Science and Technology Bureau of Quanzhou [2002CT003]
Sevoflurane is widely used in anesthesia for surgical patients, but may increase the incidence of postoperative cognitive dysfunction (POCD). POCD affects patients' lives and adds burden to patients and their families. Understanding the mechanism of Sevoflurane-induced POCD is crucial for prevention and treatment.
Sevoflurane is one of the most widely used anesthetics for the induction and maintenance of general anesthesia in surgical patients. Sevoflurane treatment may increase the incidence of postoperative cognitive dysfunction (POCD), and patients with POCD exhibit lower cognitive abilities than before the operation. POCD affects the lives of patients and places an additional burden on patients and their families. Understanding the mechanism of sevoflurane-induced POCD may improve prevention and treatment of POCD. In this paper, we review the diagnosis of POCD, introduce animal models of POCD in clinical research, analyze the possible mechanisms of sevoflurane-induced POCD, and summarize advances in treatment for this condition.
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