期刊
CURRENT STEM CELL RESEARCH & THERAPY
卷 17, 期 1, 页码 13-25出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1574888X16666210714152730
关键词
Vitamin C; reprogramming; DNA demethylation; histone demethylation; RNA demethylation; iron and 2-oxoglutarate dependent dioxygenases; somatic cell regeneration
资金
- National Natural Science Foundation of China [81702802]
- Beijing Municipal Commission of Education [KM-201810005032, KM20191000 5005]
Emerging evidence suggests that vitamin C enhances the reprogramming process by acting as a cofactor in DNA and histone demethylation. It also potentially plays a role in regulating RNA methylation and cellular reprogramming. This review highlights the significance of vitamin C in epigenetic regulation and its affiliation with demethylases in facilitating epigenetic reprogramming.
Emerging evidence suggests that ascorbic acid (vitamin C) enhances the reprogramming process by multiple mechanisms primarily due to its cofactor role in Fe(II) and 2-oxoglutarate-dependent dioxygenases, including the DNA demethylases Ten Eleven Translocase (TET) and histone demethylases. Epigenetic variations have been shown to play a critical role in somatic cell reprogramming. DNA methylation and histone methylation are extensively recognized as barriers to somatic cell reprogramming. N-6-methyladenosine (m(6)A), known as RNA methylation, is an epigenetic modification of mRNAs and has also been shown to play a role in regulating cellular reprogramming. Multiple cofactors are reported to promote the activity of these demethylases, including vitamin C. Therefore, this review focuses and examines the evidence and mechanism of vitamin C in DNA and histone demethylation and highlights its potential involvement in the regulation of m(6)A demethylation. It also shows the significant contribution of vitamin C in epigenetic regulation, and the affiliation of demethylases with vitamin C-facilitated epigenetic reprogramming.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据