期刊
CELL REPORTS
卷 36, 期 6, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109524
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资金
- National Natural Science Foundation of China [81471553, 81872530]
- National Science and Technology Major Project [2018ZX10301101]
- Frontier Research Program of Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) [2018GZR110105005]
- Dermatology Hospital, Southern Medical University
By single-cell RNA sequencing, the research revealed the dynamic changes of immune cells during skin development, providing detailed insight into the establishment of the immune system during embryonic development.
The immune system of skin develops in stages in mice. However, the developmental dynamics of immune cells in human skin remains elusive. Here, we perform transcriptome profiling of CD45(+) hematopoietic cells in human fetal skin at an estimated gestational age of 10-17 weeks by single-cell RNA sequencing. A total of 13 immune cell types are identified. Skin macrophages show dynamic heterogeneity over the course of skin development. A major shift in lymphoid cell developmental states occurs from the first to the second trimester that implies an in situ differentiation process. Gene expression analysis reveals a typical developmental program in immune cells in accordance with their functional maturation, possibly involving metabolic reprogramming. Finally, we identify transcription factors (TFs) that potentially regulate cellular transitions by comparing TFs and TF target gene networks. These findings provide detailed insight into how the immune system of the human skin is established during development.
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