期刊
CELL REPORTS
卷 36, 期 5, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109461
关键词
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类别
资金
- Royal Society [UF120046, RG080398]
- Moorfields Eye Charity [ST1209J, E170004A, R150032A, R180005A]
- Fight for Sight [1448, 1449]
- RP Fighting Blindness
- Medical Research Council UK [mr/j004553/1]
- Wellcome Trust [082217]
- UCL Grand Challenge PhD student
- Fight for Sight-funded post-doctoral research associate
- Royal Society [UF120046] Funding Source: Royal Society
Research shows that photoreceptors undergo cyclic rapid nuclear translocation during development to ensure their correct positioning in the retina. Attenuating dynein 1 function results in abnormal photoreceptor displacement and compromised synapse formation.
In development, almost all stratified neurons must migrate from their birthplace to the appropriate neural layer. Photoreceptors reside in the most apical layer of the retina, near their place of birth. Whether photoreceptors require migratory events for fine-positioning and/or retention within this layer is not well understood. Here, we show that photoreceptor nuclei of the developing mouse retina cyclically exhibit rapid, dynein-1-dependent translocation toward the apical surface, before moving more slowly in the basal direction, likely due to passive displacement by neighboring retinal nuclei. Attenuating dynein 1 function in rod photoreceptors results in their ectopic basal displacement into the outer plexiform layer and inner nuclear layer. Synapse formation is also compromised in these displaced cells. We propose that repeated, apically directed nuclear translocation events are necessary to ensure retention of post-mitotic photoreceptors within the emerging outer nuclear layer during retinogenesis, which is critical for correct neuronal lamination.
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