期刊
CELL REPORTS
卷 36, 期 5, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109488
关键词
-
类别
资金
- [R01-GM120129]
- [RF1 AG061872]
The study shows that mice lacking TXNIP have lower levels of PUFAs in their mitochondrial membrane lipids, affecting mitochondrial function and causing lower heat output. This phenotype can be rescued by a ketogenic diet, confirming the usefulness of this model in understanding early cellular damage caused by excess glucose influx.
Hyperglycemia affects over 400 million individuals worldwide. The detrimental health effects are well studied at the tissue level, but the in vivo effects at the organelle level are poorly understood. To establish such an in vivo model, we used mice lacking TXNIP, a negative regulator of glucose uptake. Examining mitochondrial function in brown adipose tissue, we find that TXNIP KO mice have a lower content of polyunsaturated fatty acids (PUFAs) in theirmembrane lipids, which affects mitochondrial integrity and electron transport chain efficiency and ultimately results in lower mitochondrial heat output. This phenotype can be rescued by a ketogenic diet, confirming the usefulness of this model and highlighting one facet of early cellular damage caused by excess glucose influx.
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