期刊
CELL REPORTS
卷 36, 期 8, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109601
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资金
- Association Francaise contre les Myopathies, Cure CMD
- Fundacion Andres Marcio
- European Research Council
- BBSRC
- MDUK
- National Institute for Health Research
Cofilins play a crucial role in regulating the actin cytoskeleton and muscle function, while mutations in the LMNA gene cause increased expression of cofilin-1 in muscle cells, leading to impaired sarcomere structure and force generation. This finding provides insight into the molecular pathogenesis of muscular dystrophies caused by LMNA mutations.
Cofilins are important for the regulation of the actin cytoskeleton, sarcomere organization, and force production. The role of cofilin-1, the non-muscle-specific isoform, in muscle function remains unclear Mutations in LMNA encoding A-type lamins, intermediate filament proteins of the nuclear envelope, cause autosomal Emery-Dreifuss muscular dystrophy (EDMD). Here, we report increased cofilin-1 expression in LMNA mutant muscle cells caused by the inability of proteasome degradation, suggesting a protective role by ERK1/2. It is known that phosphorylated ERK1/2 directly binds to and catalyzes phosphorylation of the actin-depolymerizing factor cofilin-1 on Thr25. In vivo ectopic expression of cofilin-1, as well as its phosphorylated form on Thr25, impairs sarcomere structure and force generation. These findings present a mechanism that provides insight into the molecular pathogenesis of muscular dystrophies caused by LMNA mutations.
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