期刊
CELL REPORTS
卷 36, 期 12, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109751
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类别
资金
- NIH/NIMH [R01MH099114]
- NIH/NINDS [R01NS115471]
- NCI Center Support Grant [NCI CA060553]
- Center for Advanced Microscopy at The Feinberg School of Medicine
This study demonstrates the expression of KAR glutamate receptors in adult-born dentate granule cells and their impact on the functional properties of young cells during development through interaction with GABAergic signaling mechanisms. Disruption of KARs in a cohort of young adult-born neurons in mice affected their performance in a spatial discrimination task but not in a hippocampal-dependent fear conditioning task, highlighting the importance of KARs in the proper functional development of young cells.
Both inhibitory and excitatory neurotransmitter receptors can influence maturation and survival of adult-born neurons in the dentate gyrus; nevertheless, how these two neurotransmitter systems affect integration of new neurons into the existing circuitry is still not fully characterized. Here, we demonstrate that glutamate receptors of the kainate receptor (KAR) subfamily are expressed in adult-born dentate granule cells (abDGCs) and that, through their interaction with GABAergic signaling mechanisms, they alter the functional properties of adult-born cells during a critical period of their development. Both the intrinsic properties and synaptic connectivity of young abDGCs were affected. Timed KAR loss in a cohort of young adult-born neurons in mice disrupted their performance in a spatial discrimination task but not in a hippocampal-dependent fear conditioning task. Together, these results demonstrate the importance of KARs in the proper functional development of young abDGCs.
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