期刊
CELL REPORTS
卷 35, 期 11, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109234
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资金
- NSF [NSF/IOS 1924732]
- NIH [R01 MH123260-01, RISE GMO60655, VA CDA IK2 BX004905, F31 MH105161, F32 HL143893]
Poor sleep quality is associated with age-related cognitive decline, but the possibility of reversing these changes is unknown. This study suggests that sleep deprivation may help ameliorate age-related memory deficits and allow hippocampal representations to adapt to changing environments. Successful memory performance is correlated with specific cellular phenotypes and spindle counts.
Poor sleep quality is associated with age-related cognitive decline, and whether reversal of these alterations is possible is unknown. In this study, we report how sleep deprivation (SD) affects hippocampal representations, sleep patterns, and memory in young and old mice. After training in a hippocampus-dependent object-place recognition (OPR) task, control animals sleep ad libitum, although experimental animals undergo 5 h of SD, followed by recovery sleep. Young controls and old SD mice exhibit successful OPR memory, whereas young SD and old control mice are impaired. Successful performance is associated with two cellular phenotypes: (1) context'' cells, which remain stable throughout training and testing, and (2) object configuration'' cells, which remap when objects are introduced to the context and during testing. Additionally, effective memory correlates with spindle counts during non-rapid eye movement (NREM)/rapid eye movement (REM) sigma transitions. These results suggest SD may serve to ameliorate age-related memory deficits and allow hippocampal representations to adapt to changing environments.
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