期刊
CELL AND BIOSCIENCE
卷 11, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13578-021-00617-1
关键词
Human pluripotent stem cells; Brain organoids; Neural disorders; Cancer
资金
- Fundamental Research Funds for the Central Universities [20ykzd02]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515110285]
- National Natural Science Foundation of China [32000679, 82072901]
Three-dimensional brain organoids (BOs) derived from human pluripotent stem cells (hPSCs) offer new opportunities to model brain development, neurodegenerative disorders, and brain cancers in vitro, providing a way to study these complex processes and diseases.
The sheer complexities of brain and resource limitation of human brain tissue greatly hamper our understanding of the brain disorders and cancers. Recently developed three-dimensional (3D) brain organoids (BOs) are self-organized and spontaneously differentiated from human pluripotent stem cells (hPSCs) in vitro, which exhibit similar features with cell type diversity, structural organization, and functional connectivity as the developing human brain. Based on these characteristics, hPSC-derived BOs (hPDBOs) provide new opportunities to recapitulate the complicated processes during brain development, neurodegenerative disorders, and brain cancers in vitro. In this review, we will provide an overview of existing BO models and summarize the applications of this technology in modeling the neural disorders and cancers. Furthermore, we will discuss the challenges associated with their use as in vitro models for disease modeling and the potential future direction.
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