Inferring SARS-CoV-2 functional genomics from viral transcriptome with identification of potential antiviral drugs and therapeutic targets

Article Virology

Assessment of the role of zinc in the prevention of COVID-19 infections and mortality: A retrospective study in the Asian and European population

Nurshad Ali et al.

Summary: The study found a significant positive correlation between zinc deficiency and COVID-19 cases in Asian countries, but no significant correlation with mortality; in European countries, there was a significant negative correlation between zinc deficiency and both COVID-19 cases and deaths.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Multidisciplinary Sciences

Efficacy and tolerability of bevacizumab in patients with severe Covid-19

Jiaojiao Pang et al.

Summary: In this single-arm clinical trial, the authors show that treatment of COVID-19 patients with bevacizumab, an anti-vascular endothelial growth factor drug, can improve PaO2/FiO(2) ratios and oxygen-support status. Relative to an external control group, bevacizumab shows clinical efficacy by improving oxygenation.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Network pharmacology approach to decipher signaling pathways associated with target proteins of NSAIDs against COVID-19

Ki Kwang Oh et al.

Summary: This study explored the potential efficacy of NSAIDs against COVID-19 through network pharmacology, identifying 6MNA, Rofecoxib, and Indomethacin as promising candidates for inhibiting the RAS signaling pathway and alleviating excessive inflammation induced by SARS-CoV-2.

SCIENTIFIC REPORTS (2021)

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Review Immunology