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Article
Multidisciplinary Sciences
Nicholas G. Davies et al.
Summary: A new variant of SARS-CoV-2 has emerged in England, with a higher reproduction number and potential for large resurgences of COVID-19 cases. Without stringent control measures, it is projected that COVID-19 hospitalizations and deaths in England for the first 6 months of 2021 will exceed those in 2020. The variant has spread globally and exhibited similar transmission increases in Denmark, Switzerland, and the United States.
Article
Medicine, General & Internal
Robert Challen et al.
Summary: The study found that the mortality hazard ratio associated with infection with VOC-202012/1 compared with previously circulating variants was 1.64, indicating an increase in deaths from 2.5 to 4.1 per 1000 detected cases in comparatively low risk group of covid-19 patients in the community. This suggests that infection with VOC-202012/1 may lead to substantial additional mortality compared with previously circulating variants, impacting healthcare capacity planning and control policies.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Letter
Pediatrics
Sarah Brookman et al.
LANCET CHILD & ADOLESCENT HEALTH
(2021)
Article
Infectious Diseases
Daniel J. Grint et al.
Summary: The SARS-CoV-2 B.1.1.7 VOC is spreading across Europe and poses a higher risk of death compared to non-VOC cases, with increased mortality in older individuals and those with comorbidities. This variant has the potential to spread faster and cause higher mortality than previous strains.
Article
Multidisciplinary Sciences
Nicholas G. Davies et al.
Summary: Studies have shown that the SARS-CoV-2 B.1.1.7 lineage is more transmissible and may cause more severe illness compared to pre-existing variants.
Article
Multidisciplinary Sciences
Erik Volz et al.
Summary: Genetic and testing data from England indicate that the SARS-CoV-2 variant B.1.1.7 has a transmission advantage over other lineages, showing a rapid expansion during autumn 2020. Analysis of S gene target failures (SGTF) in community-based diagnostic PCR testing suggests that B.1.1.7 is more transmissible than non-variant of concern lineages and has a significant transmission advantage, with a reproduction number 50% to 100% higher. Additionally, cases of B.1.1.7 appear to include a larger share of under 20-year-olds compared to non-variant cases.
Article
Public, Environmental & Occupational Health
T. Clare et al.
Summary: This study evaluated the completeness and timeliness of the surveillance of SARS-CoV-2 infection in England, showing high completeness of data and improving timeliness of reporting.
Article
Immunology
Alison E. Brown et al.
Summary: Among the 58,186 coronavirus deaths in adults in England during March-December 2020, the majority occurred in hospitals, in patients aged 60 and above, and within 28 days of a positive specimen. The cumulative mortality rates were highest among individuals of Black, Asian, other, or mixed ethnicities and in socioeconomically deprived areas.
EMERGING INFECTIOUS DISEASES
(2021)
