期刊
GENES BRAIN AND BEHAVIOR
卷 16, 期 2, 页码 271-284出版社
WILEY
DOI: 10.1111/gbb.12319
关键词
Anxiety; Eph receptor; ephrin-A5; estrogen; maternal care; nest building; progesterone; pup retrieval
资金
- NIH [1RO1EY019012, 2PO1HD023315, P30 ES005022, MH104800]
- NJ Commission on Brain Injury Research
- Charles and Johanna Busch grant support
During development of the nervous system, molecular signals mediating cell-cell interactions play critical roles in the guidance of axonal growth and establishment of synaptic functions. The Eph family of tyrosine kinase receptors and their ephrin ligands has been shown to mediate neuronal interactions in the development of topographic axon projection maps in several brain regions, and the loss of Eph activities result in defects in select axonal pathways. However, effects of deficiencies of the Eph signals on animal behavior have not been well documented. In this study, we showed that inactivation of a ligand of the Eph receptors, ephrin-A5, resulted in defects in maternal behavior and alterations in anxiety. Female ephrin-A5(-/-) mice show significant defects in nest building and pup retrieval. In addition, lower levels of anxiety were observed in both male and female null mice. These changes were not due to deficiencies in estradiol, progesterone or corticosterone levels. Our observations suggest that ephrin-A5 plays a key role in the development and/or function of neural pathways mediating mouse maternal care and anxiety.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据