期刊
ADVANCED HEALTHCARE MATERIALS
卷 10, 期 20, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202100970
关键词
2D materials; breath diagnosis; flexible and wearable; health care; MXene; sensor device
资金
- Universitas Airlangga through Riset mandat muda [399/UN3.14/PT2020]
- Xiamen University Malaysia Investigatorship Grant [IENG/0038]
- Japan Society for the Promotion of Science (JSPS) [16H06439, 20H00297]
- Dynamic Alliance for Open Innovations Bridging Human, Environment and Materials
- Cooperative Research Program of Network Joint Research Center for Materials and Devices
- Murata Science Foundation
The application of MXenes as emerging materials in sensor devices for detecting breath biomarkers shows multiple advantages and promising clinical prospects. These sensor devices, based on key parameters such as high surface sensitivity, large surface-to-mass ratio, room temperature detection, and ease of assembly, are crucial for achieving personalized, non-invasive, real-time, and low-cost healthcare.
A fully integrated, flexible, and functional sensing device for exhaled breath analysis drastically transforms conventional medical diagnosis to non-invasive, low-cost, real-time, and personalized health care. 2D materials based on MXenes offer multiple advantages for accurately detecting various breath biomarkers compared to conventional semiconducting oxides. High surface sensitivity, large surface-to-weight ratio, room temperature detection, and easy-to-assemble structures are vital parameters for such sensing devices in which MXenes have demonstrated all these properties both experimentally and theoretically. So far, MXenes-based flexible sensor is successfully fabricated at a lab-scale and is predicted to be translated into clinical practice within the next few years. This review presents a potential application of MXenes as emerging materials for flexible and wearable sensor devices. The biomarkers from exhaled breath are described first, with emphasis on metabolic processes and diseases indicated by abnormal biomarkers. Then, biomarkers sensing performances provided by MXenes families and the enhancement strategies are discussed. The method of fabrications toward MXenes integration into various flexible substrates is summarized. Finally, the fundamental challenges and prospects, including portable integration with Internet-of-Thing (IoT) and Artificial Intelligence (AI), are addressed to realize marketization.
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