期刊
ADVANCED HEALTHCARE MATERIALS
卷 10, 期 24, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202100736
关键词
aggregation-induced emission; detection; pathogens; phototherapy; theranostics
资金
- National Natural Science Foundation of China [52022090, 51933009]
- Zhejiang Provincial Ten Thousand Talents Program [2018R52001]
The prevention and control of pathogenic bacteria, fungi, and viruses is a global challenge in public health. AIEgens are considered as potential treatment strategies for detecting and treating related infections.
The prevention and control of pathogenic bacteria, fungi, and viruses is a herculean task for all the countries since they greatly threaten global public health. Rapid detection and effective elimination of these pathogens is crucial for the treatment of related diseases. It is urgently demanded to develop new diagnostic and therapeutic strategies to combat bacteria, fungi, and viruses-induced infections. The emergence of aggregation-induced emission (AIE) luminogens (AIEgens) is a revolutionary breakthrough for the treatment of many diseases, including pathogenic infections. In this review, the main focus is on the applications of AIEgens for theranostic treatment of pathogenic bacteria, fungi, and viruses. Due to the AIE characteristic, AIEgens are promising fluorescent probes for the detection of bacteria, fungi, and viruses with excellent sensitivity and photostability. Moreover, AIEgen-based theranostic platforms can be fabricated by introducing bactericidal moieties or designing AIE photosensitizers and AIE photothermal agents. The current strategies and ongoing developments of AIEgens for the treatment of pathogenic bacteria, fungi, and viruses will be discussed in detail.
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