期刊
ADVANCED HEALTHCARE MATERIALS
卷 10, 期 16, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202100695
关键词
hydrogels; magnetoelectric nanoparticles; neurogenesis; piezoelectric materials; remote electrical stimulation
资金
- National Natural Science Foundation of China [51973132, 51873119, 52003178]
- Postdoctoral Research Foundation of China [2020M683312]
The novel concept of a magneto-responsive electric 3D matrix has been demonstrated to enhance neurogenesis at cellular level and in spinal cord injury through the application of an external pulsed magnetic field. This research paves the way for remote control and delivery of electricity through an extracellular niche-mimicked hydrogel network, with potential applications in neurogenesis and human-computer interaction with higher resolution.
Electrical stimulation is regarded pivotal to promote repair of nerve injuries, however, failed to get extensive application in vivo due to the challenges in noninvasive electrical loading accompanying with construction of biomimetic cell niche. Herein, a new concept of magneto responsive electric 3D matrix for remote and wireless electrical stimulation is demonstrated. By the preparation of magnetoelectric core/shell structured Fe3O4@BaTiO3 NPs-loaded hyaluronan/collagen hydrogels, which recapitulate considerable magneto-electricity and vital features of native neural extracellular matrix, the enhancement of neurogenesis both in cellular level and spinal cord injury in vivo with external pulsed magnetic field applied is proved. The findings pave the way for a novel class of remote controlling and delivering electricity through extracellular niches-mimicked hydrogel network, arising prospects not only in neurogenesis but also in human-computer interaction with higher resolution.
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