相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Toward a neurospheroid niche model: optimizing embedded 3D bioprinting for fabrication of neurospheroid brain-like co-culture constructs
Yi-Chen Ethan Li et al.
BIOFABRICATION (2021)
Three-dimensionally two-photon lithography realized vascular grafts
T. Limongi et al.
BIOMEDICAL MATERIALS (2021)
Self-Organizing 3D Human Trunk Neuromuscular Organoids
Jorge-Miguel Faustino Martins et al.
CELL STEM CELL (2020)
High-resolution tomographic analysis of in vitro 3D glioblastoma tumor model under long-term drug treatment
Mehmet S. Ozturk et al.
SCIENCE ADVANCES (2020)
Vertically-Aligned Functionalized Silicon Micropillars for 3D Culture of Human Pluripotent Stem Cell-Derived Cortical Progenitors
Alessandro Cutarelli et al.
CELLS (2020)
Development of an Anisotropically Organized Brain dECM Hydrogel-Based 3D Neuronal Culture Platform for Recapitulating the Brain Microenvironment in Vivo
Yoojin Seo et al.
ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)
Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies
Yuriy Pomeshchik et al.
STEM CELL REPORTS (2020)
Toward Brain-on-a-Chip: Human Induced Pluripotent Stem Cell-Derived Guided Neuronal Networks in Tailor-Made 3D Nanoprinted Microscaffolds
Jann Harberts et al.
ACS NANO (2020)
Human organoids: model systems for human biology and medicine
Jihoon Kim et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging
Mootaz M. Salman et al.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)
Neurite guidance and neuro-caging on steps and grooves in 2.5 dimensions
Cornelius Fendler et al.
NANOSCALE ADVANCES (2020)
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids
Henrik Renner et al.
ELIFE (2020)
Can mouse models mimic sporadic Alzheimer's disease?
Bettina M. Foidl et al.
NEURAL REGENERATION RESEARCH (2020)
Interfacing human induced pluripotent stem cell-derived neurons with designed nanowire arrays as a future platform for medical applications
Jann Harberts et al.
BIOMATERIALS SCIENCE (2020)
Routine Optical Clearing of 3D-Cell Cultures: Simplicity Forward
Elina Nuernberg et al.
FRONTIERS IN MOLECULAR BIOSCIENCES (2020)
Organoids for Drug Discovery and Personalized Medicine
Toshio Takahashi
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)
Modeling neural circuit, blood-brain barrier, and myelination on a microfluidic 96 well plate
Seung-Ryeol Lee et al.
BIOFABRICATION (2019)
Automated microfluidic cell culture of stem cell derived dopaminergic neurons
Khalid I. W. Kane et al.
SCIENTIFIC REPORTS (2019)
Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids
Hongwon Kim et al.
STEM CELL REPORTS (2019)
A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy
Hee-Gyeong Yi et al.
NATURE BIOMEDICAL ENGINEERING (2019)
Synapsins regulate α-synuclein functions
Merav Atias et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Quantitative Characterization of α-Synuclein Aggregation in Living Cells through Automated Microfluidics Feedback Control
Giansimone Perrino et al.
CELL REPORTS (2019)
Optogenetic neuronal stimulation promotes axon outgrowth and myelination of motor neurons in a three-dimensional motor neuron-Schwann cell coculture model on a microfluidic biochip
Sujin Hyung et al.
BIOTECHNOLOGY AND BIOENGINEERING (2019)
Animal to human translation: a systematic scoping review of reported concordance rates
Cathalijn H. C. Leenaars et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2019)
Microfluidic Brain-on-a-Chip: Perspectives for Mimicking Neural System Disorders
Mirza Ali Mofazzal Jahromi et al.
MOLECULAR NEUROBIOLOGY (2019)
Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid
Ji Hoon Ahn et al.
NATURE (2019)
Individual brain organoids reproducibly form cell diversity of the human cerebral cortex
Silvia Velasco et al.
NATURE (2019)
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
Tae-Eun Park et al.
NATURE COMMUNICATIONS (2019)
Injured Axons Instruct Schwann Cells to Build Constricting Actin Spheres to Accelerate Axonal Disintegration
Adrien Vaquie et al.
CELL REPORTS (2019)
Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery
Marie-Laure Arotcarena et al.
CELLS (2019)
Brain-on-a-chip: A history of development and future perspective
Seokyoung Bang et al.
BIOMICROFLUIDICS (2019)
α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities
Parvez Alam et al.
JOURNAL OF NEUROCHEMISTRY (2019)
Ageing as a risk factor for neurodegenerative disease
Yujun Hou et al.
NATURE REVIEWS NEUROLOGY (2019)
Blood-Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease
Yoojin Shin et al.
ADVANCED SCIENCE (2019)
Scalable integration of nano-, and microfluidics with hybrid two-photon lithography
Oliver Vanderpoorten et al.
MICROSYSTEMS & NANOENGINEERING (2019)
Mouse induced pluripotent stem cells-derived Alzheimer's disease cerebral organoid culture and neural differentiation disorders
Wenjuan Fan et al.
NEUROSCIENCE LETTERS (2019)
Design and manufacture of 3D cell culture plate for mass production of cell-spheroids
Dongkyoung Lee et al.
SCIENTIFIC REPORTS (2019)
Serum-Free Culture of Human Mesenchymal Stem Cell Aggregates in Suspension Bioreactors for Tissue Engineering Applications
Leah M. Allen et al.
STEM CELLS INTERNATIONAL (2019)
3D Bioprinted Human Cortical Neural Constructs Derived from Induced Pluripotent Stem Cells
Federico Salaris et al.
JOURNAL OF CLINICAL MEDICINE (2019)
Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network
Simona Gribaudo et al.
STEM CELL REPORTS (2019)
Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease
Angelique di Domenico et al.
STEM CELL REPORTS (2019)
Naked Liquid Marbles: A Robust Three-Dimensional Low-Volume Cell-Culturing System
Mo Chen et al.
ACS APPLIED MATERIALS & INTERFACES (2019)
3D-Bioprinted Mini-Brain: A Glioblastoma Model to Study Cellular Interactions and Therapeutics
Marcel Alexander Heinrich et al.
ADVANCED MATERIALS (2019)
Mask-free generation of multicellular 3D heterospheroids array for high-throughput combinatorial anti-cancer drug screening
Wenguang Yang et al.
MATERIALS & DESIGN (2019)
Introducing an automated high content confocal imaging approach for Organs-on-Chips
Samantha Peel et al.
LAB ON A CHIP (2019)
Synaptic Wiring of Corticostriatal Circuits in Basal Ganglia: Insights into the Pathogenesis of Neuropsychiatric Disorders
Hsiao-Ying Kuo et al.
ENEURO (2019)
Personalised organs-on-chips: functional testing for precision medicine
Albert van den Berg et al.
LAB ON A CHIP (2019)
Reliable autapse formation using the single-cell patterning method
Seokyoung Bang et al.
BIOFABRICATION (2019)
Modeling Parkinson's disease in midbrain-like organoids
Lisa M. Smits et al.
NPJ PARKINSONS DISEASE (2019)
Microglia in Alzheimer's disease
David V. Hansen et al.
JOURNAL OF CELL BIOLOGY (2018)
A 3D Real-Scale, Biomimetic, and Biohybrid Model of the Blood-Brain Barrier Fabricated through Two-Photon Lithography
Attilio Marino et al.
SMALL (2018)
Development of an In Vitro 3D Brain Tissue Model Mimicking In Vivo-Like Pro-inflammatory and Pro-oxidative Responses
Hyung Joon Cho et al.
ANNALS OF BIOMEDICAL ENGINEERING (2018)
3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes
Marco Campisi et al.
BIOMATERIALS (2018)
Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress
Victor S. Van Laar et al.
JOURNAL OF NEUROSCIENCE (2018)
Human brain organoid-on-a-chip to model prenatal nicotine exposure
Yaqing Wang et al.
LAB ON A CHIP (2018)
An in vivo model of functional and vascularized human brain organoids
Abed AlFatah Mansour et al.
NATURE BIOTECHNOLOGY (2018)
A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease
Joseph Park et al.
NATURE NEUROSCIENCE (2018)
Human brain organoids on a chip reveal the physics of folding
Eyal Karzbrun et al.
NATURE PHYSICS (2018)
Generation of human brain region-specific organoids using a miniaturized spinning bioreactor
Xuyu Qian et al.
NATURE PROTOCOLS (2018)
Generation of human vascularized brain organoids
Missy T. Pham et al.
NEUROREPORT (2018)
Six-month cultured cerebral organoids from human ES cells contain matured neural cells
Takeshi K. Matsui et al.
NEUROSCIENCE LETTERS (2018)
α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies
Iryna Prots et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes
P. Conforti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Engineering stem cell-derived 3D brain organoids in a perfusable organ-on-a-chip system
Yaqing Wang et al.
RSC ADVANCES (2018)
Human Neurospheroid Arrays for In Vitro Studies of Alzheimer's Disease
Mehdi Jorfi et al.
SCIENTIFIC REPORTS (2018)
Engineered 3D vascular and neuronal networks in a microfluidic platform
Tatsuya Osaki et al.
SCIENTIFIC REPORTS (2018)
Translational potential of human brain organoids
Alfred X. Sun et al.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2018)
The Feasibility of Encapsulated Embryonic Medullary Reticular Cells to Grow and Differentiate Into Neurons in Functionalized Gelatin-Based Hydrogels
Ana M. Magarinos et al.
FRONTIERS IN MATERIALS (2018)
Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons
Yoonhee Jin et al.
NATURE BIOMEDICAL ENGINEERING (2018)
3D Printed Stem-Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds
Daeha Joung et al.
ADVANCED FUNCTIONAL MATERIALS (2018)
Modular microstructure design to build neuronal networks of defined functional connectivity
Csaba Forro et al.
BIOSENSORS & BIOELECTRONICS (2018)
14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic α-Synuclein
Bing Wang et al.
JOURNAL OF NEUROSCIENCE (2018)
Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease
Sandro Da Mesquita et al.
NATURE (2018)
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells
Ben M. Maoz et al.
NATURE BIOTECHNOLOGY (2018)
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature
Antoine Louveau et al.
NATURE NEUROSCIENCE (2018)
Deformable 96-well cell culture plate compatible with high-throughput screening platforms
Tsubasa S. Matsui et al.
PLOS ONE (2018)
Rapid and efficient differentiation of functional motor neurons from human iPSC for neural injury modelling
Fabio Bianchi et al.
STEM CELL RESEARCH (2018)
Advances in organ-on-a-chip engineering
Boyang Zhang et al.
NATURE REVIEWS MATERIALS (2018)
Global, regional, and national burden of Parkinson's disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
E. Ray Dorsey et al.
LANCET NEUROLOGY (2018)
Blood-brain-barrier organoids for investigating the permeability of CNS therapeutics
Sonja Bergmann et al.
NATURE PROTOCOLS (2018)
Neuroethics Questions to Guide Ethical Research in the International Brain Initiatives
Global Neuroethics Summit Delegates et al.
NEURON (2018)
The Meningeal Lymphatic System: A New Player in Neurophysiology
Sandro Da Mesquita et al.
NEURON (2018)
A perfused human blood-brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport
Nienke R. Wevers et al.
FLUIDS AND BARRIERS OF THE CNS (2018)
Digitalized Human Organoid for Wireless Phenotyping
Masaki Kimura et al.
ISCIENCE (2018)
In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system
Yaqing Wang et al.
LAB ON A CHIP (2018)
Microfluidic Blood-Brain Barrier Model Provides In Vivo-Like Barrier Properties for Drug Permeability Screening
Ying I. Wang et al.
BIOTECHNOLOGY AND BIOENGINEERING (2017)
Three-dimensional culture of single embryonic stem-derived neural/stem progenitor cells in fibrin hydrogels: neuronal network formation and matrix remodelling
Ana R. Bento et al.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)
Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device
Yuji Nashimoto et al.
INTEGRATIVE BIOLOGY (2017)
In situ generation of human brain organoids on a micropillar array
Yujuan Zhu et al.
LAB ON A CHIP (2017)
The release and trans-synaptic transmission of Tau via exosomes
Yipeng Wang et al.
MOLECULAR NEURODEGENERATION (2017)
Three-dimensional functional human neuronal networks in uncompressed low-density electrospun fiber scaffolds
Albin Jakobsson et al.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)
The use of brain organoids to investigate neural development and disease
Elizabeth Di Lullo et al.
NATURE REVIEWS NEUROSCIENCE (2017)
Modeling Physiological Events in 2D vs. 3D Cell Culture
Kayla Duval et al.
PHYSIOLOGY (2017)
A Human Brain Microphysiological System Derived from Induced Pluripotent Stem Cells to Study Neurological Diseases and Toxicity
David Pamies et al.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2017)
Recent lab-on-chip developments for novel drug discovery
Nauman Khalid et al.
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2017)
Anisotropically organized three-dimensional culture platform for reconstruction of a hippocampal neural network
So Hyun Kim et al.
NATURE COMMUNICATIONS (2017)
Low-loss modified SU-8 waveguides by direct laser writing at 405 nm
Jhonattan C. Ramirez et al.
OPTICAL MATERIALS EXPRESS (2017)
Biological Significance of the Suppression of Oxidative Phosphorylation in Induced Pluripotent Stem Cells
Cheng Zhang et al.
CELL REPORTS (2017)
Human neuron-astrocyte 3D co-culture-based assay for evaluation of neuroprotective compounds
Ana Paula Terrasso et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2017)
Three-dimensional hyaluronic acid hydrogel-based models for in vitro human iPSC-derived NPC culture and differentiation
Shaohua Wu et al.
JOURNAL OF MATERIALS CHEMISTRY B (2017)
Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells
Anna S. Monzel et al.
STEM CELL REPORTS (2017)
Three-Dimensional Cell Cultures in Drug Discovery and Development
Ye Fang et al.
SLAS DISCOVERY (2017)
A Low Permeability Microfluidic Blood-Brain Barrier Platform with Direct Contact between Perfusable Vascular Network and Astrocytes
Seokyoung Bang et al.
SCIENTIFIC REPORTS (2017)
Design of Cultured Neuron Networks in vitro with Predefined Connectivity Using Asymmetric Microfluidic Channels
Arseniy Gladkov et al.
SCIENTIFIC REPORTS (2017)
Mechanical stress regulates transport in a compliant 3D model of the blood-brain barrier
Paul P. Partyka et al.
BIOMATERIALS (2017)
Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration
Yangfei Xiang et al.
CELL STEM CELL (2017)
Direct Laser Writing of Tubular Microtowers for 3D Culture of Human Pluripotent Stem Cell-Derived Neuronal Cells
Sanna Turunen et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Towards an understanding of amyloid-β oligomers: characterization, toxicity mechanisms, and inhibitors
Shin Jung C. Lee et al.
CHEMICAL SOCIETY REVIEWS (2017)
Engineering-Aligned 3D Neural Circuit in Microfluidic Device
Seokyoung Bang et al.
ADVANCED HEALTHCARE MATERIALS (2016)
Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1
Michel Brahic et al.
ACTA NEUROPATHOLOGICA (2016)
Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
Xuyu Qian et al.
CELL (2016)
Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons
Junghyun Jo et al.
CELL STEM CELL (2016)
Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis
Christian Lange et al.
EMBO JOURNAL (2016)
Corticostriatal Dysfunction in Huntington's Disease: The Basics
Kendra D. Bunner et al.
FRONTIERS IN HUMAN NEUROSCIENCE (2016)
Neuronal activity enhances tau propagation and tau pathology in vivo
Jessica W. Wu et al.
NATURE NEUROSCIENCE (2016)
TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease
Xiaobei Zhao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Projected increase in amyotrophic lateral sclerosis from 2015 to 2040
Karissa C. Arthur et al.
NATURE COMMUNICATIONS (2016)
Functional 3D Neural Mini-Tissues from Printed Gel-Based Bioink and Human Neural Stem Cells
Qi Gu et al.
ADVANCED HEALTHCARE MATERIALS (2016)
Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients
Lin Lin et al.
CELL REPORTS (2016)
Neural Conversion and Patterning of Human Pluripotent Stem Cells: A Developmental Perspective
Alexandra Zirra et al.
STEM CELLS INTERNATIONAL (2016)
Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units
Sebastien G. M. Uzel et al.
SCIENCE ADVANCES (2016)
The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy
Urmi Sengupta et al.
EBIOMEDICINE (2016)
Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells
Han-Kyu Lee et al.
PLOS ONE (2016)
Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes
Waseem K. Raja et al.
PLOS ONE (2016)
High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform
Nienke R. Wevers et al.
SCIENTIFIC REPORTS (2016)
Astrogliosis in a dish: substrate stiffness induces astrogliosis in primary rat astrocytes
Christina L. Wilson et al.
RSC ADVANCES (2016)
Microfluidic neural axon diode
Sangcheol Na et al.
TECHNOLOGY (2016)
Development of a Scalable, High-Throughput-Compatible Assay to Detect Tau Aggregates Using iPSC-Derived Cortical Neurons Maintained in a Three-Dimensional Culture Format
X. Medda et al.
JOURNAL OF BIOMOLECULAR SCREENING (2016)
Alzheimer's in 3D culture: Challenges and perspectives
Carla D'Avanzo et al.
BIOESSAYS (2015)
3D bioprinting of neural stern cell-laden thermoresponsive biodegradable polyurethane hydrogel and potential in central nervous system repair
Fu-Yu Hsieh et al.
BIOMATERIALS (2015)
Novel scalable 3D cell based model for in vitro neurotoxicity testing: Combining human differentiated neurospheres with gene expression and functional endpoints
Ana Paula Terrasso et al.
JOURNAL OF BIOTECHNOLOGY (2015)
Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease
JiSoo Park et al.
LAB ON A CHIP (2015)
Structural and functional features of central nervous system lymphatic vessels
Antoine Louveau et al.
NATURE (2015)
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
Anca M. Pasca et al.
NATURE METHODS (2015)
A 3D human neural cell culture system for modeling Alzheimer's disease
Young Hye Kim et al.
NATURE PROTOCOLS (2015)
Measuring the effects of aging and sex on regional brain stiffness with MR elastography in healthy older adults
Arvin Arani et al.
NEUROIMAGE (2015)
3D in vitro modeling of the central nervous system
Amy M. Hopkins et al.
PROGRESS IN NEUROBIOLOGY (2015)
Ultrasoft Alginate Hydrogels Support Long-Term Three-Dimensional Functional Neuronal Networks
Gemma Palazzolo et al.
TISSUE ENGINEERING PART A (2015)
Three-Dimensional Neural Spheroid Culture: An In Vitro Model for Cortical Studies
Yu-Ting L. Dingle et al.
TISSUE ENGINEERING PART C-METHODS (2015)
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain
Shuko Takeda et al.
NATURE COMMUNICATIONS (2015)
Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue
Hideya Sakaguchi et al.
NATURE COMMUNICATIONS (2015)
Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation
Sara Calafate et al.
CELL REPORTS (2015)
Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells
Keiko Muguruma et al.
CELL REPORTS (2015)
Hydrogel: Preparation, characterization, and applications: A review
Enas M. Ahmed
JOURNAL OF ADVANCED RESEARCH (2015)
3D Cell Culture Systems: Advantages and Applications
Maddaly Ravi et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2015)
Drug discovery through stem cell-based organoid models
Adrian Ranga et al.
ADVANCED DRUG DELIVERY REVIEWS (2014)
beta-Amyloid Is Transmitted via Neuronal Connections along Axonal Membranes
Ha-Lim Song et al.
ANNALS OF NEUROLOGY (2014)
Economic analysis of opportunities to accelerate Alzheimer's disease research and development
Troy J. Scott et al.
ANNALS REPORTS (2014)
A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons
Dawei Zhang et al.
BIOMATERIALS (2014)
Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids
Byung-Ju Jin et al.
BIOMICROFLUIDICS (2014)
From pluripotency to forebrain patterning: an in vitro journey astride embryonic stem cells
Giuseppe Lupo et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2014)
iPS cells: a game changer for future medicine
Haruhisa Inoue et al.
EMBO JOURNAL (2014)
Tau Protein Modifications and Interactions: Their Role in Function and Dysfunction
Anna Mietelska-Porowska et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)
Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator
Joao Tiago S. Fernandes et al.
LAB ON A CHIP (2014)
Testing Aβ toxicity on primary CNS cultures using drug-screening microfluidic chips
A. Ruiz et al.
LAB ON A CHIP (2014)
Amyotrophic Lateral Sclerosis and Skeletal Muscle: An Update
O. Pansarasa et al.
MOLECULAR NEUROBIOLOGY (2014)
A three-dimensional human neural cell culture model of Alzheimer's disease
Se Hoon Choi et al.
NATURE (2014)
Microfluidic organs-on-chips
Sangeeta N. Bhatia et al.
NATURE BIOTECHNOLOGY (2014)
Extracellular α-synuclein-a novel and crucial factor in Lewy body diseases
He-Jin Lee et al.
NATURE REVIEWS NEUROLOGY (2014)
Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model
Sung Hoon Baik et al.
NEUROBIOLOGY OF AGING (2014)
Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-beta and glutamate
Cedric Annweiler et al.
NEUROBIOLOGY OF AGING (2014)
Engineering of Midbrain Organoids Containing Long-Lived Dopaminergic Neurons
Vannary Tieng et al.
STEM CELLS AND DEVELOPMENT (2014)
Alzheimer's disease drug-development pipeline: few candidates, frequent failures
Jeffrey L. Cummings et al.
ALZHEIMERS RESEARCH & THERAPY (2014)
Optimized SU-8 Processing for Low-Cost Microstructures Fabrication without Cleanroom Facilities
Vania C. Pinto et al.
MICROMACHINES (2014)
A Comparative View on Human Somatic Cell Sources for iPSC Generation
Stefanie Raab et al.
STEM CELLS INTERNATIONAL (2014)
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies
Simon Dujardin et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)
BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function
L. M. Griep et al.
BIOMEDICAL MICRODEVICES (2013)
Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength
Ludovic G. Vincent et al.
BIOTECHNOLOGY JOURNAL (2013)
α-Synuclein: The Long Distance Runner
Sonia George et al.
BRAIN PATHOLOGY (2013)
Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
Justine D. Miller et al.
CELL STEM CELL (2013)
Three-dimensional cell culture: the missing link in drug discovery
Susan Breslin et al.
DRUG DISCOVERY TODAY (2013)
Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons
Jessica W. Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Microtubule-based transport - basic mechanisms, traffic rules and role in neurological pathogenesis
Mariella A. M. Franker et al.
JOURNAL OF CELL SCIENCE (2013)
Calcium Entry and α-Synuclein Inclusions Elevate Dendritic Mitochondrial Oxidant Stress in Dopaminergic Neurons
Dilyan I. Dryanovski et al.
JOURNAL OF NEUROSCIENCE (2013)
Genetics of amyotrophic lateral sclerosis: an update
Sheng Chen et al.
MOLECULAR NEURODEGENERATION (2013)
Cerebral organoids model human brain development and microcephaly
Madeline A. Lancaster et al.
NATURE (2013)
The many faces of alpha-synuclein: from structure and toxicity to therapeutic target
Hilal A. Lashuel et al.
NATURE REVIEWS NEUROSCIENCE (2013)
α-Synuclein and Mitochondria: Partners in Crime?
Ken Nakamura
NEUROTHERAPEUTICS (2013)
Monetary Costs of Dementia in the United States
Michael D. Hurd et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
The Benefits of Humanized Yeast Models to Study Parkinson's Disease
V. Franssens et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)
Spheroid culture as a tool for creating 3D complex tissues
Eelco Fennema et al.
TRENDS IN BIOTECHNOLOGY (2013)
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
Changyoun Kim et al.
NATURE COMMUNICATIONS (2013)
Microfluidic Chemotaxis Platform for Differentiating the Roles of Soluble and Bound Amyloid-β on Microglial Accumulation
Hansang Cho et al.
SCIENTIFIC REPORTS (2013)
Neurotoxic amyloid beta oligomeric assemblies recreated in microfluidic platform with interstitial level of slow flow
Yoon Jung Choi et al.
SCIENTIFIC REPORTS (2013)
Surface Tension-Mediated, Concave-Microwell Arrays for Large-Scale, Simultaneous Production of Homogeneously Sized Embryoid Bodies
Gi Seok Jeong et al.
ADVANCED HEALTHCARE MATERIALS (2013)
The Role of Oxidative Stress in Parkinson's Disease
Vera Dias et al.
JOURNAL OF PARKINSONS DISEASE (2013)
Nanotopography Influences Adhesion, Spreading, and Self-Renewal of Human Embryonic Stem Cells
Weiqiang Chen et al.
ACS NANO (2012)
Overflow Microfluidic Networks: Application to the Biochemical Analysis of Brain Cell Interactions in Complex Neuroinflammatory Scenarios
Fabio Bianco et al.
ANALYTICAL CHEMISTRY (2012)
Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport
Eric C. Freundt et al.
ANNALS OF NEUROLOGY (2012)
Micro-ring structures stabilize microdroplets to enable long term spheroid culture in 384 hanging drop array plates
Amy Y. Hsiao et al.
BIOMEDICAL MICRODEVICES (2012)
High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment
Patricia Rosa et al.
BIOMICROFLUIDICS (2012)
Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases
Joshua A. Smith et al.
BRAIN RESEARCH BULLETIN (2012)
Advances in the formation, use and understanding of multi-cellular spheroids
Toni-Marie Achilli et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2012)
Matrix nanotopography as a regulator of cell function
Deok-Ho Kim et al.
JOURNAL OF CELL BIOLOGY (2012)
Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)
Ross Booth et al.
LAB ON A CHIP (2012)
3D Differentiation of Neural Stem Cells in Macroporous Photopolymerizable Hydrogel Scaffolds
Hang Li et al.
PLOS ONE (2012)
The Geometric Structure of the Brain Fiber Pathways
Van J. Wedeen et al.
SCIENCE (2012)
Amyloid-β Contributes to Blood-Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy
Anika M. S. Hartz et al.
STROKE (2012)
Novel advances in the design of three-dimensional bio-scaffolds to control cell fate: translation from 2D to 3D
Edorta Santos et al.
TRENDS IN BIOTECHNOLOGY (2012)
Pathologies of axonal transport in neurodegenerative diseases
Xin-An Liu et al.
TRANSLATIONAL NEUROSCIENCE (2012)
Soluble forms of tau are toxic in Alzheimer's disease
Katherine J. Kopeikina et al.
TRANSLATIONAL NEUROSCIENCE (2012)
Stem Cell Technology for Neurodegenerative Diseases
J. Simon Lunn et al.
ANNALS OF NEUROLOGY (2011)
Micropatterning neural cell cultures in 3D with a multi-layered scaffold
Anja Kunze et al.
BIOMATERIALS (2011)
Co-Pathological Connected Primary Neurons in a Microfluidic Device for Alzheimer Studies
Anja Kunze et al.
BIOTECHNOLOGY AND BIOENGINEERING (2011)
The Human Brain in a Dish: The Promise of iPSC-Derived Neurons
Ricardo Dolmetsch et al.
CELL (2011)
Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation Transwell models
Kathryn Hatherell et al.
JOURNAL OF NEUROSCIENCE METHODS (2011)
Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers
Jean-Michel Peyrin et al.
LAB ON A CHIP (2011)
Pathological roles of α-synuclein in neurological disorders (vol 10, pg 1015, 2011)
K. Vekrellis et al.
LANCET NEUROLOGY (2011)
Self-organizing optic-cup morphogenesis in three-dimensional culture
Mototsugu Eiraku et al.
NATURE (2011)
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
Berislav V. Zlokovic
NATURE REVIEWS NEUROSCIENCE (2011)
β-Amyloid impairs axonal BDNF retrograde trafficking
Wayne W. Poon et al.
NEUROBIOLOGY OF AGING (2011)
Control of Neural Cell Composition in Poly(Ethylene Glycol) Hydrogel Culture with Soluble Factors
Rachael Mooney et al.
TISSUE ENGINEERING PART A (2011)
From 3D cell culture to organs-on-chips
Dongeun Huh et al.
TRENDS IN CELL BIOLOGY (2011)
Pathological roles of α-synuclein in neurological disorders
Kostas Vekrellis et al.
LANCET NEUROLOGY (2011)
The effect of topology of chitosan biomaterials on the differentiation and proliferation of neural stem cells
Gan Wang et al.
ACTA BIOMATERIALIA (2010)
Compatibility of Neural Stem Cells with Functionalized Self-assembling Peptide Scaffold In vitro
Zhen Xing Zhang et al.
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING (2010)
Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease
Doris C. V. Thu et al.
BRAIN (2010)
A neuron-benign microfluidic gradient generator for studying the response of mammalian neurons towards axon guidance factors
Nirveek Bhattacharjee et al.
INTEGRATIVE BIOLOGY (2010)
Oligomeric Alpha-synuclein and Its Role in Neuronal Death
David R. Brown
IUBMB LIFE (2010)
The benefits and limitations of animal models for translational research in neurodegenerative diseases
Mathias Jucker
NATURE MEDICINE (2010)
An Overview of APP Processing Enzymes and Products
Vivian W. Chow et al.
NEUROMOLECULAR MEDICINE (2010)
Huntington's disease: a clinical review
Raymund A. C. Roos
ORPHANET JOURNAL OF RARE DISEASES (2010)
Efficient Generation of Functional Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Under Defined Conditions
Andrzej Swistowski et al.
STEM CELLS (2010)
'Too much good news' - are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?
Kathleen R. Zahs et al.
TRENDS IN NEUROSCIENCES (2010)
CAG Expansion in the Huntington Disease Gene Is Associated with a Specific and Targetable Predisposing Haplogroup
Simon C. Warby et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2009)
Microscale Control of Stiffness in a Cell-Adhesive Substrate Using Microfluidics-Based Lithography
Yuk Kee Cheung et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Models for prevention and treatment of cancer: Problems vs promises
Bharat B. Aggarwal et al.
BIOCHEMICAL PHARMACOLOGY (2009)
The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells
Akhilesh Banerjee et al.
BIOMATERIALS (2009)
Microfluidic compartmentalized co-culture platform for CNS axon myelination research
Jaewon Park et al.
BIOMEDICAL MICRODEVICES (2009)
Pathophysiology of Huntingtonʼs disease: from huntingtin functions to potential treatments
Emmanuel Roze et al.
CURRENT OPINION IN NEUROLOGY (2009)
Advancing Science and Technology Via 3D Culture on Basement Membrane Matrix
G. Benton et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Four Decades of Neurodegenerative Disease Research: How Far We Have Come!
Anne B. Young
JOURNAL OF NEUROSCIENCE (2009)
NEURON - GLIA INTERACTIONS - OPINION The bright side of the glial scar in CNS repair
Asya Rolls et al.
NATURE REVIEWS NEUROSCIENCE (2009)
A review of Parkinson's disease
C. A. Davie
BRITISH MEDICAL BULLETIN (2008)
Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease
C. -X. Gong et al.
CURRENT MEDICINAL CHEMISTRY (2008)
Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain
Anju Vasudevan et al.
NATURE NEUROSCIENCE (2008)
Synuclein activates microglia in a model of Parkinson's disease
Xiaomin Su et al.
NEUROBIOLOGY OF AGING (2008)
LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model
Babak Nazer et al.
NEUROBIOLOGY OF DISEASE (2008)
The blood-brain barrier in health and chronic neurodegenerative disorders
Berislav V. Zlokovic
NEURON (2008)
Mutant huntingtin and mitochondrial dysfunction
Ella Bossy-Wetzel et al.
TRENDS IN NEUROSCIENCES (2008)
Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber
Wajeeh Saadi et al.
BIOMEDICAL MICRODEVICES (2007)
Micropatterns of Matrigel for three-dimensional epithelial cultures
Temitope R. Sodunke et al.
BIOMATERIALS (2007)
Intracellular amyloid-β in Alzheimer's disease
Frank M. LaFerla et al.
NATURE REVIEWS NEUROSCIENCE (2007)
Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: Implications for drug therapy
Brinda S. Desai et al.
CELL TRANSPLANTATION (2007)
A network dysfunction perspective on neurodegenerative diseases
Jorge J. Palop et al.
NATURE (2006)
Establishment and characterization of multicellular spheroids from a human glioma cell line; Implications for tumor therapy
D Khaitan et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2006)
Subunit arrangement and function in NMDA receptors
H Furukawa et al.
NATURE (2005)
Gene expression perturbation in vitro - A growing case for three-dimensional (3D) culture systems
A Birgersdotter et al.
SEMINARS IN CANCER BIOLOGY (2005)
Three-dimensional tissue culture models in cancer biology
JB Kim
SEMINARS IN CANCER BIOLOGY (2005)
Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant Huntingtin
T Milakovic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery
C Zuccato et al.
PHARMACOLOGICAL RESEARCH (2005)
A microfluidic culture platform for CNS axonal injury, regeneration and transport
AM Taylor et al.
NATURE METHODS (2005)
The effect of pore size on cell adhesion in collagen-GAG scaffolds
FJ O'Brien et al.
BIOMATERIALS (2005)
Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition
Emilie Croisier et al.
JOURNAL OF NEUROINFLAMMATION (2005)
Patterned cell culture inside microfluidic devices
SW Rhee et al.
LAB ON A CHIP (2005)
Human neural stem cell growth and differentiation in a gradient-generating microfluidic device
BG Chung et al.
LAB ON A CHIP (2005)
Role of α-synuclein in presynaptic dopamine recruitment
L Yavich et al.
JOURNAL OF NEUROSCIENCE (2004)
GABAergic microcircuits in the neostriatum
JM Tepper et al.
TRENDS IN NEUROSCIENCES (2004)
Effect of collagen gel stiffness on neurite extension
RK Willits et al.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2004)
Mechanism of toxicity in rotenone models of Parkinson's disease
TB Sherer et al.
JOURNAL OF NEUROSCIENCE (2003)
14-3-3 proteins in the nervous system
D Berg et al.
NATURE REVIEWS NEUROSCIENCE (2003)
The role of α-synuclein in Parkinson's disease:: Insights from animal models
E Maries et al.
NATURE REVIEWS NEUROSCIENCE (2003)
The rotenone model of Parkinson's disease: genes, environment and mitochondria
JT Greenamyre et al.
PARKINSONISM & RELATED DISORDERS (2003)
Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types
JM Kelm et al.
BIOTECHNOLOGY AND BIOENGINEERING (2003)
Memantine in moderate-to-severe Alzheimer's disease
B Reisberg et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
Chemically-bound nerve growth factor for neural tissue engineering applications
TA Kapur et al.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2003)
Counting CAG repeats in the Huntington's disease gene by restriction endonuclease EcoP15I cleavage -: art. no. e83
E Möncke-Buchner et al.
NUCLEIC ACIDS RESEARCH (2002)
Engineering cellular microenvironments to cell-based drug testing improve
K Bhadriraju et al.
DRUG DISCOVERY TODAY (2002)
Agarose gel stiffness determines rate of DRG neurite extension in 3D cultures
AP Balgude et al.
BIOMATERIALS (2001)
Alzheimer's disease: Genes, proteins, and therapy
DJ Selkoe
PHYSIOLOGICAL REVIEWS (2001)
Mechanisms underlying hypoxia-induced neuronal apoptosis
KJ Banasiak et al.
PROGRESS IN NEUROBIOLOGY (2000)
Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems
DT Chiu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)