期刊
ADVANCED HEALTHCARE MATERIALS
卷 10, 期 12, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202002119
关键词
biomimetic matericals; brains‐ on‐ a‐ chip; brain organoids; brain spheroids; neurodegenerative diseases; pathophysiology
资金
- National Research Foundation of Korea (NRF) - Korean Government (MSIT) [2018R1A2A3075013]
- Brain Research Program of the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2018M3C7A1056896]
- Bio and Medical Technology Development Program of the National Research Foundation (NRF)
- Ministry of Food and Drug Safety [20172MFDS196]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2020R1A6A3A01098991]
- KIST Institutional Program [2E30965, 2E30966]
- Korean government (MSIT) [2020M3E5D9079742, 2020M3A9D8039920]
- Korea Sports Promotion Foundation (KSPO) [DY0002258576-20172바약안196-1] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2018M3C7A1056896, 2020M3A9D8039920, 2020R1A6A3A01098991] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Neurodegenerative diseases are characterized by progressive degeneration of the central and peripheral nervous systems. Engineered platforms like brain organoids and brain-on-a-chip can mimic the pathophysiological signatures of these diseases, offering a promising tool for research and therapy.
Neurodegenerative diseases are a group of disorders characterized by progressive degeneration of the structural and functional integrity of the central and peripheral nervous systems. Millions of people suffer from degenerative brain diseases worldwide, and the mortality continues to increase every year, causing a growing demand for knowledge of the underlying mechanisms and development of therapeutic targets. Conventional 2D-based cell culture platforms and animal models cannot fully recapitulate the pathophysiology, and this has limited the capability for estimating drug efficacy. Recently, engineered platforms, including brain organoids and brain-on-a-chip, have emerged. They mimic the physiology of brain tissue and reflect the fundamental pathophysiological signatures of neurodegenerative diseases, such as the accumulation of neurotoxic proteins, structural abnormalities, and functional loss. In this paper, recent advances in brain-mimetic platforms and their potential for modeling features of neurodegenerative diseases in vitro are reviewed. The development of a physiologically relevant model should help overcome unresolved neurodegenerative diseases.
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