期刊
GENES AND IMMUNITY
卷 17, 期 4, 页码 213-219出版社
SPRINGERNATURE
DOI: 10.1038/gene.2016.12
关键词
-
资金
- Australian NHMRC [1049936]
- National Institutes of Health (NIH) [DK057978, DK090962, HL088093, HL105278, ES010337]
- Glenn Foundation for Medical Research
- Leona M and Harry B Helmsley Charitable Trust [2012-PG-MED002]
- National Health and Medical Research Council of Australia [632886, 1043199]
The vitamin D receptor (VDR) is a ligand-activated transcription factor that regulates gene expression in many cell types, including immune cells. It requires binding of 1,25 dihydroxy vitamin D-3 (1,25D3) for activation. Many autoimmune diseases show latitude-dependent prevalence and/or association with vitamin D deficiency, and vitamin D supplementation is commonly used in their clinical management. 1,25D3 is regulated by genes associated with the risk of autoimmune diseases and predominantly expressed in myeloid cells. We determined the VDR cistrome in monocytes and monocyte-derived inflammatory (DC1) and tolerogenic dendritic cells (DC2). VDR motifs were highly overrepresented in ChIP-Seq peaks in stimulated monocyte (40%), DC1 (21%) and DC2 (47%), P
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据