期刊
SCIENTIFIC REPORTS
卷 11, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-021-95667-3
关键词
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资金
- NIHR Manchester BRC
- Hungarian Respiratory Society research grants
- Erasmus+ program (The European Unions)
This study found that patients with OSA had more lumbar abnormalities compared to non-OSA controls, and markers of OSA severity were correlated with the development of lumbar spondylosis in these patients.
Previous studies suggested cervical spondylosis as a risk factor for development of obstructive sleep apnoea (OSA). We aimed to assess lumbar disc degeneration in patients with OSA and correlate the findings with symptoms and disease severity. Twenty-seven patients with OSA and 29 non-OSA controls underwent sleep studies and lumbar magnetic resonance imaging (MRI), and completed the Epworth Sleepiness Scale and the 24-item Roland-Morris Disability Questionnaire (RMDQ) questionnaires. Plasma klotho was determined with enzyme-linked immunosorbent assay. Patients with OSA had higher number of disc bulges (4.6 +/- 3.7 vs. 1.7 +/- 2.5, p < 0.01) and anterior spondylophytes (2.7 +/- 4.2 vs. 0.8 +/- 2.1, p < 0.01), increased disc degeneration (total Pfirrmann score 16.7 +/- 4.7 vs. 13.2 +/- 4.1, p < 0.01) and vertebral fatty degeneration (7.8 +/- 4.7 vs. 3.8 +/- 3.7, p < 0.01). There was no difference in the RMDQ score (0/0-3.5/ vs. 0/0-1/, p > 0.05). Markers of OSA severity, including the oxygen desaturation index and percentage of total sleep time spent with saturation < 90% as well as plasma levels of klotho were correlated with the number of disc bulges and anterior spondylophytes (all p < 0.05). OSA is associated with lumbar spondylosis. Our study highlights the importance of lumbar imaging in patients with OSA reporting lower back pain.
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