期刊
GENES & DEVELOPMENT
卷 30, 期 9, 页码 1047-1057出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.279448.116
关键词
sensory neurons; aging; C. elegans; insulin-like peptide; DAF-16/FOXO
资金
- Ministry of Education, Science, and Technology through the National Research Foundation (NRF) of Korea [NRF-2012R1A4A1028200]
- Seokchun Daewoong Foundation
- DGIST R&D Program of the Ministry of Science, ICT, and Future Planning [16-BD-06]
- National Institutes of Health/National Institute of General Medical Sciences [R01GM108962]
- Future Basic Science Program [NRF-2013H1A8A1003751]
- Ministry of Science, ICT & Future Planning, Republic of Korea [16-BD-06] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Environmental fluctuations influence organismal aging by affecting various regulatory systems. One such system involves sensory neurons, which affect life span in many species. However, how sensory neurons coordinate organismal aging in response to changes in environmental signals remains elusive. Here, we found that a subset of sensory neurons shortens Caenorhabditis elegans' life span by differentially regulating the expression of a specific insulin-like peptide (ILP), INS-6. Notably, treatment with food-derived cues or optogenetic activation of sensory neurons significantly increases ins-6 expression and decreases life span. INS-6 in turn relays the longevity signals to nonneuronal tissues by decreasing the activity of the transcription factor DAF-16/FOXO. Together, our study delineates a mechanism through which environmental sensory cues regulate aging rates by modulating the activities of specific sensory neurons and ILPs.
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