期刊
GENES & DEVELOPMENT
卷 30, 期 13, 页码 1483-1491出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.280578.116
关键词
DNA replication; telomerase; telomere
资金
- National Institutes of Health [AG009383, CA160300]
- Allegheny Health Network Cancer Research Fund
Telomere length is regulated around an equilibrium set point. Telomeres shorten during replication and are lengthened by telomerase. Disruption of the length equilibrium leads to disease; thus, it is important to understand the mechanisms that regulate length at the molecular level. The prevailing protein-counting model for regulating telomerase access to elongate the telomere does not explain accumulating evidence of a role of DNA replication in telomere length regulation. Here I present an alternative model: the replication fork model that can explain how passage of a replication fork and regulation of origin firing affect telomere length.
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